Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/133265
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Therapeutic modulators of hepatic stellate cells for hepatocellular carcinoma |
Author: | Ruan, Q. Wang, H. Burke, L.J. Bridle, K.R. Li, X. Zhao, C.X. Crawford, D.H.G. Roberts, M.S. Liang, X. |
Citation: | International Journal of Cancer, 2020; 147(6):1519-1527 |
Publisher: | Wiley |
Issue Date: | 2020 |
ISSN: | 0020-7136 1097-0215 |
Statement of Responsibility: | Qi Ruan, Haolu Wang, Leslie J. Burke, Kim R. Bridle, Xinxing Li, Chun-Xia Zhao, Darrell H.G. Crawford, Michael S. Roberts, and Xiaowen Liang |
Abstract: | Hepatocellular carcinoma (HCC) is the most common type of primary tumor in the liver and is a leading cause of cancer-related death worldwide. Activated hepatic stellate cells (HSCs) are key components of the HCC microenvironment and play an important role in the onset and progression of HCC through the secretion of growth factors and cytokines. Current treatment modalities that include chemotherapy, radiotherapy and ablation are able to activate HSCs and remodel the tumor microenvironment. Growing evidence has demonstrated that the complex interaction between activated HSCs and tumor cells can facilitate cancer chemoresistance and metastasis. Therefore, therapeutic targeting of activated HSCs has emerged as a promising strategy to improve treatment outcomes for HCC. This review summarizes the molecular mechanisms of HSC activation triggered by treatment modalities, the function of activated HSCs in HCC, as well as the crosstalk between tumor cells and activated HSCs. Pathways of activated HSC reduction are discussed, including inhibition, apoptosis, and reversion to the inactivated state. Finally, we outline the progress and challenges of therapeutic approaches targeting activated HSCs in the development of HCC treatment. |
Keywords: | Hepatic Stellate Cells Carcinoma, Hepatocellular Therapeutic modulators Liver Animals Humans Liver Neoplasms Disease Progression Neovascularization, Pathologic Antineoplastic Combined Chemotherapy Protocols Cell Communication Signal Transduction Cell Proliferation Tumor Escape Drug Resistance, Neoplasm Molecular Targeted Therapy Tumor Microenvironment Chemoradiotherapy Radiofrequency Ablation |
Rights: | © 2020 UICC |
DOI: | 10.1002/ijc.32899 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1125794 |
Published version: | http://dx.doi.org/10.1002/ijc.32899 |
Appears in Collections: | Chemical Engineering publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.