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https://hdl.handle.net/2440/133114
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Type: | Journal article |
Title: | Development of core-shell nanoparticle drug delivery systems based on biomimetic mineralization |
Author: | Yang, G. Liu, Y. Jin, S. Zhao, C.X. |
Citation: | ChemBioChem: a European journal of chemical biology, 2020; 21(20):2871-2879 |
Publisher: | Wiley |
Issue Date: | 2020 |
ISSN: | 1439-4227 1439-7633 |
Statement of Responsibility: | Guangze Yang, Yun Liu, Song Jin, Chun-Xia Zhao |
Abstract: | Among various drug-delivery systems, core-shell nanoparticles have many advantages. Inspired by nature, biomimetic synthesis has emerged as a new strategy for making core-shell nanoparticles in recent years. Biomimetic mineralization is the process by which living organisms produce minerals based on biomolecule templating that leads to the formation of hierarchically structured organic-inorganic materials. In this minireview, we mainly focus on the synthesis of core-shell nanoparticle drug-delivery systems by biomimetic mineralization. We review various biomimetic mineralization methods for fabricating core-shell nanoparticles including silica-based, calcium-based and other nanoparticles, and their applications in drug delivery. We also summarize strategies for drug loading in the biomolecule-mineralized core-shell NPs. Current challenges and future directions are also discussed. |
Keywords: | biomimetic mineralization biomimetic synthesis core-shell drug delivery nanoparticles |
Rights: | © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim |
DOI: | 10.1002/cbic.202000105 |
Grant ID: | http://purl.org/au-research/grants/arc/DP150100798 http://purl.org/au-research/grants/arc/FT140100726 http://purl.org/au-research/grants/arc/DP200101238 |
Published version: | http://dx.doi.org/10.1002/cbic.202000105 |
Appears in Collections: | Chemical Engineering publications |
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