Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/132953
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Type: | Journal article |
Title: | Cohort profile: indigenous human papillomavirus and oropharyngeal squamous cell carcinoma study - a prospective longitudinal cohort |
Author: | Jamieson, L.M. Garvey, G. Hedges, J. Leane, C. Hill, I. Brown, A. Ju, X. Sethi, S. Roder, D. Logan, R.M. Johnson, N. Smith, M. Antonsson, A. Canfell, K. |
Citation: | BMJ Open, 2021; 11(6):e046928-1-e046928-11 |
Publisher: | BMJ |
Issue Date: | 2021 |
ISSN: | 2044-6055 2044-6055 |
Statement of Responsibility: | Lisa M Jamieson, Gail Garvey, Joanne Hedges, Cathy Leane, Isaac Hill, Alex Brown ... et al. |
Abstract: | Purpose Our aims are to: (1) estimate prevalence, incidence, clearance and persistence of oral human papillomavirus (HPV) infection among Indigenous Australians; (2) identify risk factors associated with oropharyngeal squamous cell carcinoma (OPSCC)-related HPV types (HPV 16 or 18); (3) develop HPV-related health state valuations and; (4) determine the impact on OPSCC and cervical cancers, and the cost-effectiveness of extending publicly-funded HPV vaccination among Indigenous Australians. Participants Participants were recruited from February 2018 to January 2019. Twelve-month follow-up occurred from March 2019 to March 2020. Participants provided socio-demographic characteristics, health-related behaviours including tobacco and alcohol use and sexual history. Health state preferences in regard to HPV vaccination, knowledge regarding HPV infection, OPSCC and cervical cancer were collected using a two-stage standard gamble approach. Participants provided saliva samples and DNA for microbial genotyping was extracted. Findings to date Of the 910 participants who were positive for β-globin at baseline, 35% had any oral HPV infection. The most prevalent HPV types were 13 or 32 (Heck’s disease; 23%). The second most prevalent types were associated with OPSCC (HPV 16 or 18; 3.3%). Of the 645 participants who were positive for β-globin at 12-month follow-up, 43% had any HPV infection. Of these, 33% were HPV types 13 or 32 and 2.5% were HPV 16 or 18. Some 588 participants had β-globin positive oral samples at baseline and 12-month follow-up. The prevalence of any oral HPV infection increased from 34% at baseline to 44% at 12-month follow-up; due to increases in HPV types 13 or 32 (20% at baseline and 34% at 12-month follow-up). Future plans Further funding will be sought to continue follow-up of this cohort, and to include (after a full medical history) a thorough clinical examination of the external head and neck; a complete oral examination and examination of the oropharynx. Blood tests for early stage OPSCC will also be undertaken. |
Keywords: | Humans Papillomaviridae Papillomavirus Infections Carcinoma, Squamous Cell Head and Neck Neoplasms Oropharyngeal Neoplasms Prospective Studies Australia Female Alphapapillomavirus Squamous Cell Carcinoma of Head and Neck |
Rights: | © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
DOI: | 10.1136/bmjopen-2020-046928 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1120215 http://purl.org/au-research/grants/nhmrc/1102587 http://purl.org/au-research/grants/nhmrc/1159491 http://purl.org/au-research/grants/nhmrc/1176651 |
Published version: | https://www.bmj.com/ |
Appears in Collections: | Public Health publications |
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hdl_132953.pdf | Published version | 592.45 kB | Adobe PDF | View/Open |
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