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https://hdl.handle.net/2440/132653
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Type: | Journal article |
Title: | Brain structure and neurological and behavioural functioning in infants born preterm |
Author: | Kelly, C.E. Thompson, D.K. Cheong, J.L.Y. Chen, J. Olsen, J.E. Eeles, A.L. Walsh, J.M. Seal, M.L. Anderson, P.J. Doyle, L.W. Spittle, A.J. |
Citation: | Developmental Medicine and Child Neurology, 2019; 61(7):820-831 |
Publisher: | Wiley |
Issue Date: | 2019 |
ISSN: | 0012-1622 1469-8749 |
Statement of Responsibility: | Claire E Kelly, Deanne K Thompson, Jeanie LY Cheong, Jian Chen, Joy E Olsen ... et al. |
Abstract: | AIM:To examine: (1) relationships between brain structure, and concurrently assessed neurological and behavioural functioning, in infants born preterm at term-equivalent age (TEA; approximately 38-44wks); and (2) whether brain structure-function relationships differ between infants born very (24-29wks) and moderate-late (32-36wks) preterm. METHOD:A total of 257 infants (91 very preterm, 166 moderate-late preterm; 120 males, 137 females) had structural magnetic resonance imaging (MRI) and neurological and behavioural assessments (Prechtl's general movements assessment, Neonatal Intensive Care Unit Network Neurobehavioral Scale [NNNS] and Hammersmith Neonatal Neurological Examination [HNNE]). Two hundred and sixty-three infants (90 very preterm, 173 moderate-late preterm; 131 males, 132 females) had diffusion MRI and assessments. Associations were investigated between assessment scores and global brain volumes using linear regressions, regional brain volumes using Voxel-Based Morphometry, and white matter microstructure using Tract-Based Spatial Statistics. RESULTS:Suboptimal scores on some assessments were associated with lower fractional anisotropy and/or higher axial, radial, and mean diffusivities in some tracts: NNNS attention and reflexes, and HNNE total score and tone, were associated with the corpus callosum and optic radiation; NNNS quality of movement with the corona radiata; HNNE abnormal signs with several major tracts. Brain structure-function associations generally did not differ between the very and moderate-late preterm groups. INTERPRETATION:White matter microstructural alterations may be associated with suboptimal neurological and behavioural performance in some domains at TEA in infants born preterm. Brain structure-function relationships are similar for infants born very preterm and moderate-late preterm. WHAT THIS PAPER ADDS:Brain volume is not related to neurological/behavioural function in infants born preterm at term. White matter microstructure is related to some neurological/behavioural domains at term. Brain-behaviour relationships are generally similar for infants born very preterm and moderate-late preterm. |
Keywords: | Brain Humans Diffusion Magnetic Resonance Imaging Reflex Organ Size Longitudinal Studies Prospective Studies Infant Behavior Movement Infant Infant, Premature Female Male White Matter |
Rights: | © 2018 Mac Keith Press |
DOI: | 10.1111/dmcn.14084 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1028822 http://purl.org/au-research/grants/nhmrc/1024516 http://purl.org/au-research/grants/nhmrc/546519 http://purl.org/au-research/grants/nhmrc/1060733 http://purl.org/au-research/grants/nhmrc/1085754 http://purl.org/au-research/grants/nhmrc/1108714 http://purl.org/au-research/grants/nhmrc/1012236 http://purl.org/au-research/grants/nhmrc/1053767 http://purl.org/au-research/grants/nhmrc/1053787 |
Published version: | http://dx.doi.org/10.1111/dmcn.14084 |
Appears in Collections: | Medicine publications |
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