Adelaide Research & Scholarship
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https://hdl.handle.net/2440/132041
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| Type: | Journal article |
| Title: | ZIF-C for targeted RNA interference and CRISPR/Cas9 based gene editing in prostate cancer |
| Author: | Poddar, A. Pyreddy, S. Carraro, F. Dhakal, S. Rassell, A. Field, M.R. Reddy, T.S. Falcaro, P. Doherty, C.M. Shukla, R. |
| Citation: | Chemical Communications, 2020; 56(98):15406-15409 |
| Publisher: | Royal Society of Chemistry |
| Issue Date: | 2020 |
| ISSN: | 1359-7345 1364-548X |
| Statement of Responsibility: | Arpita Poddar, Suneela Pyreddy, Francesco Carraro, Sudip Dhakal, Andrea Rassell, Matthew R. Field, T. Srinivasa Reddy, Paolo Falcaro, Cara M. Doherty and Ravi Shukla |
| Abstract: | Gene therapy is highly suited for prostate cancer (PC). Metal-organic-frameworks (MOFs) are potential gene delivery systems. Target-specific cytoplasmic and nuclear knockdown in host gene expression using ZIF-C is shown for the first time through RNAi and CRISPR/Cas9 based gene editing in PC cells. A green tea phytochemical coating enhances intracellular delivery. |
| Keywords: | CRISPR-Associated Protein 9, |
| Rights: | This journal is © The Royal Society of Chemistry 2020 |
| DOI: | 10.1039/d0cc06241c |
| Grant ID: | NHMRC |
| Published version: | http://dx.doi.org/10.1039/d0cc06241c |
| Appears in Collections: | Medicine publications |
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