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https://hdl.handle.net/2440/129230
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dc.contributor.author | Shalapour, S. | - |
dc.contributor.author | Lin, X.-J. | - |
dc.contributor.author | Bastian, I.N. | - |
dc.contributor.author | Brain, J. | - |
dc.contributor.author | Burt, A.D. | - |
dc.contributor.author | Aksenov, A.A. | - |
dc.contributor.author | Vrbanac, A.F. | - |
dc.contributor.author | Li, W. | - |
dc.contributor.author | Perkins, A. | - |
dc.contributor.author | Matsutani, T. | - |
dc.contributor.author | Zhong, Z. | - |
dc.contributor.author | Dhar, D. | - |
dc.contributor.author | Navas-Molina, J.A. | - |
dc.contributor.author | Xu, J. | - |
dc.contributor.author | Loomba, R. | - |
dc.contributor.author | Downes, M. | - |
dc.contributor.author | Yu, R.T. | - |
dc.contributor.author | Evans, R.M. | - |
dc.contributor.author | Dorrestein, P.C. | - |
dc.contributor.author | Knight, R. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Nature, 2017; 551(7680):340-345 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.issn | 1476-4687 | - |
dc.identifier.uri | http://hdl.handle.net/2440/129230 | - |
dc.description.abstract | The role of adaptive immunity in early cancer development is controversial. Here we show that chronic inflammation and fibrosis in humans and mice with non-alcoholic fatty liver disease is accompanied by accumulation of liver-resident immunoglobulin-A-producing (IgA+) cells. These cells also express programmed death ligand 1 (PD-L1) and interleukin-10, and directly suppress liver cytotoxic CD8+ T lymphocytes, which prevent emergence of hepatocellular carcinoma and express a limited repertoire of T-cell receptors against tumour-associated antigens. Whereas CD8+ T-cell ablation accelerates hepatocellular carcinoma, genetic or pharmacological interference with IgA+ cell generation attenuates liver carcinogenesis and induces cytotoxic T-lymphocyte-mediated regression of established hepatocellular carcinoma. These findings establish the importance of inflammation-induced suppression of cytotoxic CD8+ T-lymphocyte activation as a tumour-promoting mechanism. | - |
dc.description.statementofresponsibility | Shabnam Shalapour, Xue-Jia Lin, Ingmar N. Bastian, John Brain, Alastair D. Burt, Alexander A. Aksenov, Alison F. Vrbanac, Weihua Li, Andres Perkins, Takaji Matsutani, Zhenyu Zhong, Debanjan Dhar, Jose A. Navas-Molina, Jun Xu, Rohit Loomba, Michael Downes, Ruth T. Yu, Ronald M. Evans, Pieter C. Dorrestein, Rob Knight, Christopher Benner, Quentin M. Anstee, Michael Karin | - |
dc.language.iso | en | - |
dc.publisher | Springer Nature | - |
dc.rights | © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1038/nature24302 | - |
dc.subject | Plasma cells | - |
dc.title | Inflammation-induced IgA⁺ cells dismantle anti-liver cancer immunity | - |
dc.title.alternative | Inflammation-induced IgA(+) cells dismantle anti-liver cancer immunity | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/nature24302 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Burt, A.D. [0000-0002-3011-7774] | - |
Appears in Collections: | Aurora harvest 8 Medicine publications |
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