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https://hdl.handle.net/2440/129036
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Type: | Journal article |
Title: | Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair |
Author: | Ahangar, P. Mills, S.J. Cowin, A.J. |
Citation: | International Journal of Molecular Sciences, 2020; 21(19):1-15 |
Publisher: | MDPI AG |
Issue Date: | 2020 |
ISSN: | 1422-0067 1422-0067 |
Statement of Responsibility: | Parinaz Ahangar, Stuart J. Mills and Allison J. Cowin |
Abstract: | The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cytokines, referred to as the MSC secretome, that has considerable potential for the treatment of cutaneous wounds as a cell-free therapy. In this review, we outline the current status of MSCs as a treatment for cutaneous wounds and introduce the potential of the MSC secretome as a cell-free alternative for wound repair. We discuss the challenges and provide insights and perspectives for the future development of the MSC secretome as well as identify its potential clinical translation into a therapeutic treatment. |
Keywords: | mesenchymal stem cells secretome wound healing |
Rights: | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.3390/ijms21197038 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1002009 |
Published version: | http://dx.doi.org/10.3390/ijms21197038 |
Appears in Collections: | Aurora harvest 4 Chemistry and Physics publications |
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