Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/128319
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Effects of proximal and distal enteral glucose infusion on cardiovascular response in health and type 2 diabetes |
Author: | Zhang, X. Jones, K.L. Horowitz, M. Rayner, C.K. Wu, T. |
Citation: | Journal of Clinical Endocrinology and Metabolism, 2020; 105(8):2877-2884 |
Publisher: | Oxford University Press |
Issue Date: | 2020 |
ISSN: | 0021-972X 1945-7197 |
Statement of Responsibility: | Xiang Zhang, Karen L Jones, Michael Horowitz, Christopher K Rayner, Tongzhi Wu |
Abstract: | CONTEXT: Exposure of the small intestine to nutrients frequently leads to marked reductions in blood pressure (BP) in type 2 diabetes (T2DM). It remains unclear whether the region of the gut exposed to nutrients influences postprandial cardiovascular responses. OBJECTIVE: To evaluated the cardiovascular responses to proximal and distal small intestinal glucose infusion in health and T2DM. DESIGN: Double-blind, randomised, crossover design. SETTING: Single center in Australia. PATIENTS: 10 healthy subjects and 10 T2DM patients. INTERVENTIONS: Volunteers were studied on two occasions, when a transnasal catheter was positioned with infusion ports opening 13cm and 190cm beyond the pylorus. 30g glucose was infused into either site and 0.9% saline into the alternate site over 60min. MAIN OUTCOME MEASURES: BP, heart rate (HR) and superior mesenteric artery (SMA) blood flow were measured over 180min. RESULTS: Systolic BP was unchanged in response to both infusions in health, but decreased in T2DM, with a greater reduction after proximal vs. distal infusion (all P≤0.01). The increment in HR did not differ between treatments in health, but was greater after distal vs. proximal infusion in T2DM (P=0.02). The increases in SMA blood flow were initially greater, but less sustained, with proximal vs. distal infusion in health (P<0.001), a pattern less evident in T2DM. CONCLUSIONS: In T2DM, postprandial hypotension may be mitigated by diversion of nutrients from the proximal to the distal small intestine. |
Keywords: | Cardiovascular function Diabetes Enteral infusion type 2 |
Description: | Published: 04 June 2020 |
Rights: | © Endocrine Society 2020. All rights reserved. |
DOI: | 10.1210/clinem/dgaa341 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1066815 |
Published version: | http://dx.doi.org/10.1210/clinem/dgaa341 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.