Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/127399
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Type: Journal article
Title: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders: evidence through univariate and multivariate mega-analysis including 6420 participants from the ENIGMA MDD working group
Author: Opel, N.
Thalamuthu, A.
Milaneschi, Y.
Grotegerd, D.
Flint, C.
Leenings, R.
Goltermann, J.
Richter, M.
Hahn, T.
Woditsch, G.
Berger, K.
Hermesdorf, M.
McIntosh, A.
Whalley, H.
Harris, M.
MacMaster, F.
Walter, H.
Veer, I.
Frodl, T.
Carballedo, A.
et al.
Citation: Molecular Psychiatry, 2020; OnlinePubl:1-14
Publisher: Springer
Issue Date: 2020
ISSN: 1359-4184
1476-5578
Statement of
Responsibility: 
Nils Opel, Anbupalam Thalamuthu, Yuri Milaneschi, Dominik Grotegerd, Claas Flint ... Bernhard T. Baune ... et al.
Abstract: Emerging evidence suggests that obesity impacts brain physiology at multiple levels. Here we aimed to clarify the relationship between obesity and brain structure using structural MRI (n = 6420) and genetic data (n = 3907) from the ENIGMA Major Depressive Disorder (MDD) working group. Obesity (BMI > 30) was significantly associated with cortical and subcortical abnormalities in both mass-univariate and multivariate pattern recognition analyses independent of MDD diagnosis. The most pronounced effects were found for associations between obesity and lower temporo-frontal cortical thickness (maximum Cohen´s d (left fusiform gyrus) = −0.33). The observed regional distribution and effect size of cortical thickness reductions in obesity revealed considerable similarities with corresponding patterns of lower cortical thickness in previously published studies of neuropsychiatric disorders. A higher polygenic risk score for obesity significantly correlated with lower occipital surface area. In addition, a significant age-by-obesity interaction on cortical thickness emerged driven by lower thickness in older participants. Our findings suggest a neurobiological interaction between obesity and brain structure under physiological and pathological brain conditions.
Description: Published online: 28 May 2020
Rights: © The Author(s), under exclusive licence to Springer Nature Limited 2020
RMID: 1000021463
DOI: 10.1038/s41380-020-0774-9
Grant ID: http://purl.org/au-research/grants/nhmrc/1140764
http://purl.org/au-research/grants/nhmrc/1064643
http://purl.org/au-research/grants/nhmrc/1024570
http://purl.org/au-research/grants/nhmrc/566529
http://purl.org/au-research/grants/nhmrc/264611
http://purl.org/au-research/grants/nhmrc/402864
http://purl.org/au-research/grants/nhmrc/464914
Appears in Collections:Psychiatry publications

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