Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/120185
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Thirteen-year outcomes in very preterm children associated with diffuse excessive high signal intensity on neonatal magnetic resonance imaging |
Author: | Murner-Lavanchy, I.M. Kidokoro, H. Thompson, D.K. Doyle, L.W. Cheong, J.L.Y. Hunt, R.W. Inder, T.E. Anderson, P.J. |
Citation: | Journal of Pediatrics, 2019; 206:66-1-66-7 |
Publisher: | Elsevier |
Issue Date: | 2019 |
ISSN: | 0022-3476 1097-6833 |
Statement of Responsibility: | Ines M. Mürner-Lavanchy, Hiroyuki Kidokoro, Deanne K. Thompson, Lex W. Doyle, Jeanie L. Y. Cheong, Rod W. Hunt, Terrie E. Inder, Peter J. Anderson |
Abstract: | Objective: To investigate the association between white matter diffuse excessive high signal intensity (DEHSI) on neonatal magnetic resonance imaging in very preterm infants and neurobehavioral outcomes at the age of 13 years. Study design: Magnetic resonance images of very preterm children (<30 weeks gestational age or <1250 g birth weight) were evaluated at term-equivalent age with DEHSI classified into 5 grades. Additionally, visibility of the posterior periventricular crossroads was assessed. General intelligence, memory, attention, executive function, motor abilities, and behavior were examined in 125 children at age 13 years and related to DEHSI grades using linear regression. Results: DEHSI was detected in 93% of infants; 21% grade 1, 22% grade 2, 32% grade 3, and 18% grade 4. Neurobehavioral outcomes were similar for all DEHSI groups. There was weak evidence that higher DEHSI grades related to higher verbal IQ and attention and that lower DEHSI grades related to better planning ability. Adjustment for gestational age, birth weight standard score, and sex further weakened these effects. Only 12 children had invisible posterior crossroads and showed slightly poorer outcomes at 13 years of age. Conclusions: There was little evidence that neonatal DEHSI serves as a sensitive biomarker for later impairment. Further investigation on the importance of invisible posterior periventricular crossroads in larger samples is needed. |
Keywords: | Humans Infant, Premature, Diseases Magnetic Resonance Imaging Longitudinal Studies Follow-Up Studies Neuropsychological Tests Gestational Age Image Processing, Computer-Assisted Adolescent Child Infant, Newborn Infant, Very Low Birth Weight Victoria Female Male Infant, Extremely Premature White Matter Behavior Rating Scale |
Rights: | © 2018 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.jpeds.2018.10.016 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/546519 http://purl.org/au-research/grants/nhmrc/1060733 http://purl.org/au-research/grants/nhmrc/1085754 http://purl.org/au-research/grants/nhmrc/1141354 http://purl.org/au-research/grants/nhmrc/1012236 http://purl.org/au-research/grants/nhmrc/1053787 http://purl.org/au-research/grants/nhmrc/237117 http://purl.org/au-research/grants/nhmrc/491209 http://purl.org/au-research/grants/nhmrc/1081288 |
Published version: | http://dx.doi.org/10.1016/j.jpeds.2018.10.016 |
Appears in Collections: | Aurora harvest 4 Dentistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.