Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/117423
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Type: Journal article
Title: Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance
Author: Stringer, J.
Forster, S.
Qu, Z.
Prokopuk, L.
O'Bryan, M.
Gardner, D.
White, S.
Adelson, D.
Western, P.
Citation: BMC Biology, 2018; 16(1):104-104
Publisher: BMC
Issue Date: 2018
ISSN: 1741-7007
1741-7007
Statement of
Responsibility: 
Jessica M. Stringer, Samuel C. Forster, Zhipeng Qu, Lexie Prokopuk, Moira K. O’Bryan, David K. Gardner, Stefan J. White, David Adelson and Patrick S. Western
Abstract: BACKGROUND: Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that regulate epigenetic information in the germline and its transmission to offspring are poorly understood. RESULTS: Here we provide evidence that Polycomb Repressive Complex 2 (PRC2) regulates paternal inheritance. Reduced PRC2 function in mice resulted in male sub-fertility and altered epigenetic and transcriptional control of retrotransposed elements in foetal male germ cells. Males with reduced PRC2 function produced offspring that over-expressed retrotransposed pseudogenes and had altered preimplantation embryo cleavage rates and cell cycle control. CONCLUSION: This study reveals a novel role for the histone-modifying complex, PRC2, in paternal intergenerational transmission of epigenetic effects on offspring, with important implications for understanding disease inheritance.
Keywords: Epigenetic reprogramming
Fertility
Germline
H3K27me3
PRC2
Paternal inheritance
Rights: © Western et al. 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
DOI: 10.1186/s12915-018-0569-5
Grant ID: http://purl.org/au-research/grants/nhmrc/1043939
http://purl.org/au-research/grants/nhmrc/1058356
http://purl.org/au-research/grants/nhmrc/1091097
http://purl.org/au-research/grants/nhmrc/1051223
Appears in Collections:Aurora harvest 3
Environment Institute publications

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