Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/115638
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Type: | Journal article |
Title: | Using routinely collected data to understand and predict adverse outcomes in opioid agonist treatment: Protocol for the Opioid Agonist Treatment Safety (OATS) Study |
Author: | Larney, S. Hickman, M. Fiellin, D.A. Dobbins, T. Nielsen, S. Jones, N.R. Mattick, R.P. Ali, R. Degenhardt, L. |
Citation: | BMJ Open, 2018; 8(8):e025204-1-e025204-6 |
Publisher: | BMJ Journals |
Issue Date: | 2018 |
ISSN: | 2044-6055 2044-6055 |
Statement of Responsibility: | Sarah Larney, Matthew Hickman, David A Fiellin, Timothy Dobbins, Suzanne Nielsen, Nicola R Jones, Richard P Mattick, Robert Ali, Louisa Degenhardt |
Abstract: | Introduction: North America is amid an opioid use epidemic. Opioid agonist treatment (OAT) effectively reduces extramedical opioid use and related harms. As with all pharmacological treatments, there are risks associated with OAT, including fatal overdose. There is a need to better understand risk for adverse outcomes during and after OAT, and for innovative approaches to identifying people at greatest risk of adverse outcomes. The Opioid Agonist Treatment and Safety study aims to address these questions so as to inform the expansion of OAT in the USA. Methods and analysis: This is a retrospective cohort study using linked, routinely collected health data for all people seeking OAT in New South Wales, Australia, between 2001 and 2017. Linked data include hospitalisation, emergency department presentation, mental health diagnoses, incarceration and mortality. We will use standard regression techniques to model the magnitude and risk factors for adverse outcomes (eg, mortality, unplanned hospitalisation and emergency department presentation, and unplanned treatment cessation) during and after OAT, and machine learning approaches to develop a risk-prediction model. Ethics and dissemination: This study has been approved by the Population and Health Services Research Ethics Committee (2018HRE0205). Results will be reported in accordance with the REporting of studies Conducted using Observational Routinely-collected health Data statement. |
Keywords: | buprenorphine |
Description: | First published August 5, 2018 |
Rights: | © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
DOI: | 10.1136/bmjopen-2018-025204 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1140938 http://purl.org/au-research/grants/nhmrc/1135991 http://purl.org/au-research/grants/nhmrc/1132433 |
Published version: | http://dx.doi.org/10.1136/bmjopen-2018-025204 |
Appears in Collections: | Aurora harvest 8 Pharmacology publications |
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hdl_115638.pdf | Published version | 228.49 kB | Adobe PDF | View/Open |
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