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https://hdl.handle.net/2440/11340
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dc.contributor.author | Rozek, T. | - |
dc.contributor.author | Waugh, R. | - |
dc.contributor.author | Steinborner, S. | - |
dc.contributor.author | Bowie, J. | - |
dc.contributor.author | Tyler, M. | - |
dc.contributor.author | Wallace, J. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Journal of Peptide Science, 1998; 4(2):111-115 | - |
dc.identifier.issn | 1075-2617 | - |
dc.identifier.issn | 1099-1387 | - |
dc.identifier.uri | http://hdl.handle.net/2440/11340 | - |
dc.description.abstract | Six peptides have been isolated and characterized from the dorsal glands of the tree frog Litoria genimaculata. One of these is the known hypotensive peptide caerulein; the others have been named maculatins. The amino acid sequences of the maculatin peptides have been determined using a combination of fast atom bombardment mass spectrometry and automated Edman sequencing. Four of the maculatin peptides show antibiotic activity, with maculatin 1.1 [GLFGVLAKVAAHVVPAIAEHF(NH2)] showing the most pronounced activity, particularly against gram-positive organisms. Maculatin 1.1 resembles the known caerin 1 antibiotic peptides, except that four of the central amino acid residues (of the caerin 1 system) are missing in maculatin 1.1. A comparison of the antibiotic activity of maculatin 1.1 with those of caerin 1.1 is reported. | - |
dc.description.statementofresponsibility | Tomas Rozek, Russell J. Waugh, Simon T. Steinborner, John H. Bowie, Michael J. Tyler, John C. Wallace | - |
dc.language.iso | en | - |
dc.publisher | JOHN WILEY & SONS LTD | - |
dc.rights | © 1998 European Peptide Society and John Wiley & Sons, Ltd. | - |
dc.source.uri | http://dx.doi.org/10.1002/(sici)1099-1387(199804)4:2%3C111::aid-psc134%3E3.0.co;2-8 | - |
dc.subject | Litoria genimaculata | - |
dc.subject | skin glands | - |
dc.subject | glandular secretions | - |
dc.subject | peptides | - |
dc.subject | antibiotic activity | - |
dc.subject | maculatins 1 | - |
dc.subject | caerin 1.1 | - |
dc.title | The maculatin peptides from the skin glands of the tree frog litoria genimaculata: a comparison of the structures and antibacterial activities of Maculatin 1.1 and Caerin 1.1 | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/(SICI)1099-1387(199804)4:2<111::AID-PSC134>3.0.CO;2-8 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 7 Biochemistry publications |
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