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https://hdl.handle.net/2440/112258
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dc.contributor.author | Yu, C. | - |
dc.contributor.author | Baune, B. | - |
dc.contributor.author | Wong, M. | - |
dc.contributor.author | Licinio, J. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Journal of Affective Disorders, 2018; 232:305-309 | - |
dc.identifier.issn | 0165-0327 | - |
dc.identifier.issn | 1573-2517 | - |
dc.identifier.uri | http://hdl.handle.net/2440/112258 | - |
dc.description | Available online 24 February 2018 | - |
dc.description.abstract | Background: Major depressive disorder (MDD) is a leading contributor to global disease burden. Recent studies have shown that genetic factors play significant roles in the susceptibility to this condition; however, the underlying genetic basis currently remains largely unknown. Short tandem repeat (STR) has been proposed as an explanatory factor in the “missing heritability” of complex diseases or traits. Methods: We investigated STR variations from 15 MDD patients and 10 ethnically matched healthy controls based on their deep whole-genome sequencing (WGS) data. The lobSTR software was used to computationally determine STRs. Results: The results of the Mexican-American sample showed that STRs are significantly richer in healthy controls than in MDD cases on each of the 23 chromosomes (all false discovery rates, FDR P-values< 0.0062); while for the Australian of European-ancestry sample, there was no statistically significant STRs difference between MDD cases and controls. Limitations: High quality WGS costs limited obtaining larger datasets. Conclusions: This preliminary work is the first study that STR variations are applied to investigate MDD based on WGS data. The results on Mexican-American population may imply that within the same ancestry, targeted sequencing on a specific chromosome or region of genome would be sufficient for examining the relationship between STR and MDD. Further studies should examine larger sequencing datasets on other ethnic groups. | - |
dc.description.statementofresponsibility | Chenglong Yu, Bernhard T. Baune, Ma-Li Wong, Julio Licinio | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.rights | © 2018 Elsevier B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jad.2018.02.046 | - |
dc.subject | Major depressive disorder | - |
dc.subject | Heritability | - |
dc.subject | Psychiatric genetics | - |
dc.subject | Whole-genome sequencing | - |
dc.subject | Genetic marker | - |
dc.title | Investigation of short tandem repeats in major depression using whole-genome sequencing data | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jad.2018.02.046 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1051931 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1060524 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Yu, C. [0000-0002-3248-8421] | - |
dc.identifier.orcid | Baune, B. [0000-0001-6548-426X] | - |
dc.identifier.orcid | Wong, M. [0000-0003-1512-3073] | - |
dc.identifier.orcid | Licinio, J. [0000-0001-6905-5884] | - |
Appears in Collections: | Aurora harvest 3 Psychiatry publications |
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