Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/110935
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DC Field | Value | Language |
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dc.contributor.author | Phillips, P. | - |
dc.contributor.author | Sasadeus, J. | - |
dc.contributor.author | Hodsman, G. | - |
dc.contributor.author | Horowitz, J. | - |
dc.contributor.author | Saltups, A. | - |
dc.contributor.author | Johnston, C. | - |
dc.date.issued | 1989 | - |
dc.identifier.citation | Heart, 1989; 61(2):139-143 | - |
dc.identifier.issn | 0007-0769 | - |
dc.identifier.issn | 1355-6037 | - |
dc.identifier.uri | http://hdl.handle.net/2440/110935 | - |
dc.description | Published Online First: 01 Sep 1989. | - |
dc.description.abstract | Plasma concentrations of immunoreactive atrial natriuretic peptide (mean (SEM] were measured in 135 patients admitted to two coronary care units with myocardial infarction, ischaemic chest pain, or non-ischaemic chest pain. Concentrations were significantly higher in patients with acute myocardial infarction not treated with systemic thrombolysis (60.4 (14.3) pg/ml) than in patients with non-ischaemic chest pain (21.1 (4.3) pg/ml). Patients with ischaemic chest pain had intermediate values (39.3 (7.1) pg/ml). Patients with acute myocardial infarction treated with intravenous streptokinase had normal concentrations of plasma atrial natriuretic peptide (20.2 (3.6) pg/mg), which were significantly lower than those in patients with myocardial infarction not given streptokinase. These changes could not be explained by factors such as age, pre-existing hypertension, renal dysfunction, or cardiac failure, nor treatment other than streptokinase. Raised plasma concentrations of atrial natriuretic peptide in acute myocardial infarction may be a homoeostatic response acting to reduce atrial pressures by natriuresis, diuresis, and venodilatation. The lower concentrations of atrial natriuretic peptide in patients with acute myocardial infarction treated with streptokinase may reflect a short term beneficial haemodynamic effect of streptokinase. | - |
dc.description.statementofresponsibility | P A Phillips, J Sasadeus, G P Hodsman, J Horowitz, A Saltups, C I Johnston | - |
dc.language.iso | en | - |
dc.publisher | BMJ Publishing Group | - |
dc.rights | Copyright status unknown | - |
dc.source.uri | http://dx.doi.org/10.1136/hrt.61.2.139 | - |
dc.subject | Atrial Natriuretic Factor | - |
dc.title | Plasma atrial natriuretic peptide in patients with acute myocardial infarction: effects of streptokinase | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1136/hrt.61.2.139 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Phillips, P. [0000-0002-9985-7631] | - |
dc.identifier.orcid | Horowitz, J. [0000-0001-6883-0703] | - |
Appears in Collections: | Aurora harvest 3 Public Health publications |
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