Type: | Journal article |
Title: | Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults |
Author: | Graff, M. Scott, R. Justice, A. Young, K. Feitosa, M. Barata, L. Winkler, T. Chu, A. Mahajan, A. Hadley, D. Xue, L. Workalemahu, T. Heard-Costa, N. den Hoed, M. Ahluwalia, T. Qi, Q. Ngwa, J. Renström, F. Quaye, L. Eicher, J. et al. |
Citation: | PLoS Genetics, 2017; 13(4):e1006528-1-e1006528-26 |
Publisher: | Public Library of Science |
Issue Date: | 2017 |
ISSN: | 1553-7390 1553-7404 |
Editor: | Edwards, T. |
Statement of Responsibility: | Mariaelisa Graff ... Lyle J. Palmer ... et al. |
Abstract: | Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery. |
Keywords: | Body mass index; genome-wide association study |
Rights: | This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
DOI: | 10.1371/journal.pgen.1006528 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/241944 http://purl.org/au-research/grants/nhmrc/339462 http://purl.org/au-research/grants/nhmrc/389927 http://purl.org/au-research/grants/nhmrc/389875 http://purl.org/au-research/grants/nhmrc/389891 http://purl.org/au-research/grants/nhmrc/389892 http://purl.org/au-research/grants/nhmrc/389938 http://purl.org/au-research/grants/nhmrc/442915 http://purl.org/au-research/grants/nhmrc/442981 http://purl.org/au-research/grants/nhmrc/496739 http://purl.org/au-research/grants/nhmrc/552485 http://purl.org/au-research/grants/nhmrc/552498 FP6 LSHG-CT-2006-01947 FP7 HEALTH-F4-2007-201413 FP7 279143, FP7 201668 FP7 305739 FP6 LSHG-CT-2006-018947 QLG1-CT-2001-01252 R01-HL087641 R01-HL59367 R01HL-086694 R24-HD050924 U01-HG-004402 HHSN268200625226C UL1-RR025005 UL1-TR-001079 UL1-TR-00040 AA07535 AA10248 AA11998 AA13320 AA13321 AA13326 AA14041 AA17688 DA12854 MH66206 R01-D004215701A R01-DK075787 R01-DK089256 U01-HG007376 5R01-HL08767902 5R01-MH63706:02 HG004790 N01-WH22110 U01-HG007033 UM1CA182913 24152 32100-2 32105-6 32108-9 32111-13 32115 32118-32119 32122 42107-26 4212932 44221 HHSN268201300028C HHSN268201300029C HHSN2682015000011 HL36310 HG002651 HL034594 HL054457 HL054481 HL071981 HL084729 HL119443 HL126024 N01-AG12100 N01-AG12109 N01-HC25195 N01-HC55015 N01-HC55016 N0-1HC55018 N01-HC55019 N01-HC55020 N0-1HC55021 R01-HD057194 N01-HC55022 N01-HD95159 N0-1HD95160 N01-HD95161 N01-HD95162 N01-HD95163 N01-HD95164 N01-HD95165 N01-HD95166 N01-HD95167 N01-HD95168 N01-HD95169 N01-HG65403 N02-HL64278 HL087660 HL100245 R01DK089256 2T32HL007055-36 U01-HL072515-06 U01-HL84756 NIA-U01AG009740 RC2-AG036495 RC4-AG039029 R03-AG046389 263-MA-410953 263-MD-9164 263-MD-821336 U01-HG004802 R37CA54281 RO1CA63 P01CA33619 U01-CA136792 U01-CA98758 RC2-MH089951 MH085520 R01-D0042157-01A MH081802 1RC2-MH089951 1RC2-MH089995 1RL1MH08326801 HHSN268201300027C R01-DK8925601 R01-HL088451 R01-HL117078 R01-DK062370 R01-DK072193 DK091718 DK100383 DK078616 1Z01-HG000024 |
Published version: | http://dx.doi.org/10.1371/journal.pgen.1006528 |
Appears in Collections: | Aurora harvest 8 Translational Health Science publications
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