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https://hdl.handle.net/2440/104176
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Type: | Journal article |
Title: | Inter-regulation of gastric emptying and incretin hormone secretion: implications for postprandial glycemic control |
Author: | Wu, T. Rayner, C. Horowitz, M. |
Citation: | Biomarkers in Medicine, 2016; 10(11):1167-1179 |
Publisher: | Future Medicine Ltd. |
Issue Date: | 2016 |
ISSN: | 1752-0363 1752-0371 |
Statement of Responsibility: | Tongzhi Wu, Christopher K Rayner, Michael Horowitz |
Abstract: | The GI tract is central to the regulation of postprandial glycemia, with the rate of gastric emptying and the secretion of the incretin hormones, glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1, being key determinants. Gastric emptying exhibits a large interindividual variation; the latter not only accounts for differences in postprandial glycemia but also determines postprandial incretin profiles. Accordingly, the rate of gastric emptying may affect the glucose-lowering efficacy of dipeptidyl peptidase-4 inhibitors. In contrast, glucagon-like peptide-1 receptor agonists lower postprandial glycemia predominantly by their action to slow gastric emptying. This review discusses the inter-relationship between gastric emptying and the incretin axis in the context of changes in blood glucose, with an emphasis on the relevant clinical implications. |
Keywords: | dietary intervention |
Rights: | Copyright status unknown |
DOI: | 10.2217/bmm-2016-0164 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.2217/bmm-2016-0164 |
Appears in Collections: | Aurora harvest 7 Medicine publications |
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