Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/103914
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Type: Journal article
Title: Cervical abnormalities are more common among Indigenous than other Australian women: a retrospective record-linkage study, 2000-2011
Author: Whop, L.
Baade, P.
Garvey, G.
Cunningham, J.
Brotherton, J.
Lokuge, K.
Valery, P.
O'Connell, D.
Canfell, K.
Diaz, A.
Roder, D.
Gertig, D.
Moore, S.
Condon, J.
Citation: PLoS One, 2016; 11(4):e0150473-1-e0150473-12
Publisher: Public Library of Science
Issue Date: 2016
ISSN: 1932-6203
1932-6203
Statement of
Responsibility: 
Lisa J. Whop, Peter Baade, Gail Garvey, Joan Cunningham, Julia M. L. Brotherton, Kamalini Lokuge, Patricia C. Valery, Dianne L. O, Connell, Karen Canfell, Abbey Diaz, David Roder, Dorota M. Gertig, Suzanne P. Moore, John R. Condon
Abstract: Indigenous Australian women have much higher incidence of cervical cancer compared to non-Indigenous women. Despite an organised cervical screening program introduced 25 years ago, a paucity of Indigenous-identified data in Pap Smear Registers remains. Prevalence of cervical abnormalities detected among the screened Indigenous population has not previously been reported. We conducted a retrospective cohort study of population-based linked health records for 1,334,795 female Queensland residents aged 20–69 years who had one or more Pap smears during 2000–2011; from linked hospital records 23,483 were identified as Indigenous. Prevalence was calculated separately for Indigenous and non-Indigenous women, for cytology-detected low-grade (cLGA) and high-grade abnormalities (cHGA), and histologically confirmed high-grade abnormalities (hHGA). Odds ratios (OR) were estimated from logistic regression analysis. In 2010–2011 the prevalence of hHGA among Indigenous women (16.6 per 1000 women screened, 95% confidence interval [CI] 14.6–18.9) was twice that of non-Indigenous women (7.5 per 1000 women screened, CI 7.3–7.7). Adjusted for age, area-level disadvantage and place of residence, Indigenous women had higher prevalence of cLGA (OR 1.4, CI 1.3–1.4), cHGA (OR 2.2, CI 2.1–2.3) and hHGA (OR 2.0, CI 1.9–2.1). Our findings show that Indigenous women recorded on the Pap Smear Register have much higher prevalence for cLGA, cHGA and hHGA compared to non-Indigenous women. The renewed cervical screening program, to be implemented in 2017, offers opportunities to reduce the burden of abnormalities and invasive cancer among Indigenous women and address long-standing data deficiencies.
Keywords: Cervix Uteri; Humans; Adenocarcinoma; Neoplasm Invasiveness; Vaginal Smears; Prognosis; Cytological Techniques; Prevalence; Risk Factors; Retrospective Studies; Follow-Up Studies; Geography; Information Storage and Retrieval; Adult; Aged; Middle Aged; Population Groups; Australia; Uterine Cervical Neoplasms; Female; Early Detection of Cancer; Electronic Health Records; Neoplasm Grading; Papanicolaou Test; Squamous Intraepithelial Lesions of the Cervix
Rights: © 2016 Whop et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
RMID: 0030064790
DOI: 10.1371/journal.pone.0150473
Grant ID: http://purl.org/au-research/grants/nhmrc/1058244
http://purl.org/au-research/grants/nhmrc/1083090
http://purl.org/au-research/grants/nhmrc/1055587
http://purl.org/au-research/grants/nhmrc/1045591
Appears in Collections:Public Health publications

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