Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/102065
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dini, S. | - |
dc.contributor.author | Binder, B. | - |
dc.contributor.author | Fischer, S. | - |
dc.contributor.author | Mattheyer, C. | - |
dc.contributor.author | Schmitz, A. | - |
dc.contributor.author | Stelzer, E. | - |
dc.contributor.author | Bean, N. | - |
dc.contributor.author | Green, J. | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Journal of the Royal Society Interface, 2016; 13(123):20160649-1-20160649-11 | - |
dc.identifier.issn | 1742-5689 | - |
dc.identifier.issn | 1742-5662 | - |
dc.identifier.uri | http://hdl.handle.net/2440/102065 | - |
dc.description.abstract | Automatic identification of the necrotic zone boundary is important in the assessment of treatments on in vitro tumour spheroids. This has been difficult especially when the difference in cell density between the necrotic and viable zones of a tumour spheroid is small. To help overcome this problem, we developed novel one-dimensional pair-correlation functions (PCFs) to provide quantitative estimates of the radial distance of the necrotic zone boundary from the centre of a tumour spheroid. We validate our approach on synthetic tumour spheroids in which the position of the necrotic zone boundary is known a priori. It is then applied to nine real tumour spheroids imaged with light sheet-based fluorescence microscopy. PCF estimates of the necrotic zone boundary are compared with those of a human expert and an existing standard computational method. | - |
dc.description.statementofresponsibility | S. Dini, B. J. Binder, S. C. Fischer, C. Mattheyer, A. Schmitz, E. H. K. Stelzer, N. G. Bean and J. E. F. Green | - |
dc.language.iso | en | - |
dc.publisher | The Royal Society | - |
dc.rights | © 2016 The Author(s) Published by the Royal Society. All rights reserved. | - |
dc.source.uri | http://rsif.royalsocietypublishing.org/content/13/123/20160649 | - |
dc.subject | tumour spheroid; necrotic zone; pair-correlation function | - |
dc.title | Identifying the necrotic zone boundary in tumour spheroids with pair-correlation functions | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1098/rsif.2016.0649 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DE130100031 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1069757 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP160102644 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/CE140100049 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Binder, B. [0000-0002-1812-6715] | - |
dc.identifier.orcid | Bean, N. [0000-0002-5351-3104] | - |
dc.identifier.orcid | Green, J. [0000-0001-5061-9563] | - |
Appears in Collections: | Aurora harvest 7 Mathematical Sciences publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_102065.pdf | Accepted Version | 2.57 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.