Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/9618
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Type: | Journal article |
Title: | High dietary intake of phytosterol esters decreases carotenoids and increases plasma plant sterol levels with no additional cholesterol lowering |
Author: | Clifton, P. Noakes, M. Ross, D. Fassoulakis, A. Cehun, M. Nestel, P. |
Citation: | Journal of Lipid Research, 2004; 45(8):1493-1499 |
Publisher: | Amer Soc Biochemistry Molecular Biology Inc |
Issue Date: | 2004 |
ISSN: | 0022-2275 1539-7262 |
Abstract: | The objective of this study was to measure the effects on serum lipids and plasma phytosterols of 6.6 g/day phytosterols from three foods (bread, breakfast cereal, and spread) consumed for 12 weeks compared with a diet that was not enriched with phytosterols. Thirty-five subjects undertook a nonrandomized, single-blind study consisting of a 2 week baseline period, 6 weeks on high-phytosterol intake, 6 weeks on high-phytosterol intake plus increased fruit and vegetable intake, and a final 2 week washout period. Serum total cholesterol decreased by 8.3% from 6.59 to 6.04 mmol/l, and LDL cholesterol decreased by 12.6% from 4.44 to 3.88 mmol/l. Plasma phytosterol levels increased by 45% (sitosterol) and 105% (campesterol). Cholesterol-adjusted plasma alpha- and beta-carotene levels decreased by 19-23%, lutein by 14%, and lycopene by 11%. Levels of alpha-carotene and lutein increased with extra fruit and vegetables. Only lycopene failed to increase during the washout phase. There were no significant changes in biochemical parameters. Serum LDL cholesterol lowering with 6.6 g/day ingested phytosterols was in the range seen with 1.6-3.2 g/day phytosterols. Lowering of plasma carotenoids was greater than that seen with lower phytosterol intake and was partially reversed by increased fruit and vegetable intake. |
Keywords: | Humans Carotenoids Cholesterol Phytosterols Body Mass Index Diet Female Male |
DOI: | 10.1194/jlr.M400074-JLR200 |
Published version: | http://dx.doi.org/10.1194/jlr.m400074-jlr200 |
Appears in Collections: | Aurora harvest Medicine publications |
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