Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/9414
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Type: Journal article
Title: Relationship between the effects of cisapride on gastric emptying and plasma glucose concentrations in diabetic gastroparesis
Author: Horowitz, M.
Jones, K.
Harding, P.
Wishart, J.
Citation: Digestion, 2002; 65(1):41-46
Publisher: Karger
Issue Date: 2002
ISSN: 0012-2823
1421-9867
Statement of
Responsibility: 
Michael Horowitz, Karen L. Jones, Philip E. Harding, Judith M. Wishart
Abstract: The effect of erythromycin on gastric emptying is attenuated during hyperglycaemia. The aim of this study was to determine in patients with diabetic gastroparesis whether the effect of cisapride on gastric emptying of solids and liquids is influenced by the plasma glucose concentration.Nineteen patients with type 1 diabetes mellitus, who had delayed gastric emptying of solids and/or liquids, were studied. On 2 separate days, each patient received cisapride (20 mg) or placebo orally 60 min before scintigraphic measurement of gastric emptying of a mixed solid (ground beef) and liquid (dextrose) meal. The plasma glucose concentrations were measured at -5, 30, 60, 90, and 120 min during each gastric emptying measurement.Cisapride accelerated both solid (retention at 100 min 43 +/- 4 vs. 69 +/- 4%, p < 0.001) and liquid (T50 27 +/- 2 vs. 39 +/- 2 min, p < 0.001) gastric emptying. The mean plasma glucose level was not significantly different after placebo when compared with cisapride (19.5 +/- 1.1 vs. 18.2 +/- 1.0 mmol/l). The change in the 50% emptying time (T50) for liquid, but not solid, emptying was related (r = 0.55, p = 0.01) to the change in the plasma glucose AUC from 0 to 30 min between the placebo and cisapride tests, i.e., the acceleration was greater if the plasma glucose concentration was relatively less during the gastric emptying test performed on cisapride.The effect of cisapride on gastric emptying, at least that of liquids, in patients with diabetic gastroparesis appears to be dependent on the plasma glucose concentration.
Keywords: gastric emptying; diabetes mellitus; cisapride; blood glucose
Rights: Copyright © 2002 S. Karger AG, Basel
RMID: 0020020777
DOI: 10.1159/000051930
Appears in Collections:Medicine publications

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