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https://hdl.handle.net/2440/9405
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Type: | Journal article |
Title: | Relationships of upper gastrointestinal motor and sensory function with glycemic control |
Author: | Rayner, C. Samsom, M. Jones, K. Horowitz, M. |
Citation: | Diabetes Care, 2001; 24(2):371-381 |
Publisher: | Amer Diabetes Assoc |
Issue Date: | 2001 |
ISSN: | 0149-5992 1935-5548 |
Statement of Responsibility: | Christopher K. Rayner, Melvin Samsom, Karen L. Jones and Michael Horowitz |
Abstract: | Acute changes in the blood glucose concentration have a major reversible effect on esophageal, gastric, intestinal, gallbladder, and anorectal motility in both healthy subjects and diabetic patients. For example, gastric emptying is slower during hyperglycemia than euglycemia and accelerated during hypoglycemia. Acute hyperglycemia also affects perceptions arising from the gastrointestinal tract and may, accordingly, be important in the etiology of gastrointestinal symptoms in diabetes. Elevations in blood glucose that are within the normal postprandial range also affect gastrointestinal motor and sensory function. Upper gastrointestinal motor function is a critical determinant of postprandial blood glucose concentrations by influencing the absorption of ingested nutrients. Interventions that reduce postprandial hyperglycemia, by modulating the rate of gastric emptying, have the potential to become mainstream therapies in the treatment of diabetes. |
Keywords: | Digestive System Intestine, Small Esophagus Stomach Humans Diabetes Mellitus Hyperglycemia Hypoglycemia Glucose Blood Glucose Sensation Gastrointestinal Motility Gastric Emptying |
Description: | Copyright © 2001 American Diabetes Association |
DOI: | 10.2337/diacare.24.2.371 |
Published version: | http://dx.doi.org/10.2337/diacare.24.2.371 |
Appears in Collections: | Aurora harvest Medicine publications |
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