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https://hdl.handle.net/2440/9183
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Type: | Journal article |
Title: | Effect of the motilin agonist KC 11458 on gastric emptying in diabetic gastroparesis |
Author: | Russo, A. Stevens, J. Giles, N. Krause, G. O'Donovan, D. Horowitz, M. Jones, K. |
Citation: | Alimentary Pharmacology and Therapeutics, 2004; 20(3):333-338 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2004 |
ISSN: | 0269-2813 1365-2036 |
Statement of Responsibility: | A. Russo, J. E. Stevens, N. Giles, G. Krause, D. G. O’Donovan, M. Horowitz & K. L. Jones |
Abstract: | Background: KC 11458, a motilin agonist without antibiotic properties, accelerates gastric emptying in animals and healthy humans. Aim: To evaluate the acute effects of KC 11458 on gastric emptying in diabetic gastroparesis. Methods: Twenty-nine patients (6 type 1 and 23 type 2) with gastroparesis underwent assessments of: (i) gastric emptying of a solid/liquid meal using scintigraphy, (ii) glycaemic control (blood glucose at 0, 30, 60, 90 and 120 min during the gastric emptying measurement) and (iii) upper gastrointestinal and ‘meal-related’ symptoms (questionnaire), at baseline and after treatment with KC 11458 in a dose of 8 mg t.d.s., or placebo for 8 days. Results: KC 11458 had no statistically significant or clinically relevant effect on gastric emptying of either the solid intragastric retention at 100 min (T100) (P ¼ 0.87) or liquid 50% emptying time (T50) (P ¼ 0.17) components of the meal. KC 11458 slightly worsened (P ¼ 0.04) upper gastrointestinal symptoms when compared with placebo. The magnitude of the change in solid gastric emptying correlated with the change in the blood glucose concentration (r ¼ 0.49; P < 0.05). Conclusions: KC 11458, in a dose of 8 mg t.d.s. for 8 days, does not accelerate gastric emptying in patients with diabetic gastroparesis. The absence of efficacy may relate to an effect of hyperglycaemia. |
Keywords: | Humans Gastroparesis Autonomic Nervous System Diseases Diabetic Neuropathies Diabetes Mellitus Erythromycin Motilin Blood Glucose Gastric Emptying Middle Aged Female Male |
Description: | The definitive version is available at www.blackwell-synergy.com Article first published online: 9 JUL 2004 |
Rights: | © 2004 Blackwell Publishing Ltd |
DOI: | 10.1111/j.1365-2036.2004.02066.x |
Published version: | http://dx.doi.org/10.1111/j.1365-2036.2004.02066.x |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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