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https://hdl.handle.net/2440/9151
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Type: | Journal article |
Title: | Effects of insulin-like growth factor-1 (IGF-1) administration on radiation enteritis in rats. |
Author: | Howarth, G. Fraser, R. Frisby, C. Yeoh, E. Schirmer, M. |
Citation: | Scandinavian Journal of Gastroenterology, 1997; 32(11):1118-1124 |
Publisher: | SCANDINAVIAN UNIVERSITY PRESS |
Issue Date: | 1997 |
ISSN: | 0036-5521 1502-7708 |
Abstract: | <h4>Background</h4>Acute radiation-induced damage to the small bowel occurs frequently during abdominal radiotherapy. Since the small intestine is selectively responsive to the growth-promoting effects of insulin-like growth factor-I (IGF-I), we investigated the effects of IGF-I administration on mucosal recovery from radiation enteritis in the rat.<h4>Methods</h4>Rats received a single 10-Gy dose of total abdominal irradiation followed by implantation of mini-pumps infusing either IGF-I or vehicle for 4 days. After the rats had been killed, gut organs were weighed before light microscopic and biochemical examination.<h4>Results</h4>Irradiated rats receiving IGF-I lost less body weight than vehicle-treated rats, whereas the wet weights of the stomach, small intestine, and colon were increased by 10%, 19%, and 21%, respectively, and crypt depth was increased in the duodenum, jejunum, and ileum.<h4>Conclusions</h4>IGF-I administration after abdominal irradiation increased small-intestinal mass and improved indicators of mucosal integrity, suggesting acceleration of small-intestinal mucosal recovery from radiation injury. |
Keywords: | Intestinal Mucosa Colon Intestine, Small Duodenum Ileum Jejunum Stomach Animals Rats Rats, Sprague-Dawley Enteritis Radiation Injuries, Experimental Disease Models, Animal Body Weight Insulin-Like Growth Factor I Organ Size Radiation, Ionizing Male |
DOI: | 10.3109/00365529709002990 |
Published version: | http://dx.doi.org/10.3109/00365529709002990 |
Appears in Collections: | Aurora harvest Medicine publications |
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