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https://hdl.handle.net/2440/88519
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Type: | Journal article |
Title: | Biochemical cardiovascular risk factors after hypertensive pregnancy disorders: a systematic review and meta-analysis |
Author: | Hermes, W. Ket, J. van Pampus, M. Franx, A. Veenendaal, M. Kolster, C. Tamsma, J. Bloemenkamp, K. Ponjee, G. van der Hout, E. ten Horn, H. Loix, S. Mol, B. de Groot, C. |
Citation: | Obstetrical and Gynecological Survey, 2012; 67(12):793-809 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2012 |
ISSN: | 0029-7828 1533-9866 |
Statement of Responsibility: | Wietske Hermes, Johannes C.F. Ket, Maria G. van Pampus, Arie Franx, Marjolein V.E. Veenendaal, Clara Kolster, Jouke T. Tamsma, L Kitty W. M. Bloemenkamp, Gabrielle Ponjee, Evelien van der Hout, Hilde ten Horn, Stéphanie Loix, Ben Willem Mol, and Christianne J.M. de Groot |
Abstract: | The objective of this study was to perform a systematic review and meta-analysis of studies assessing biochemical cardiovascular risk factors in women with previous hypertensive pregnancy disorders and women with previous normotensive pregnancies. Data were collected from PubMed and EMBASE (from inception to February 28, 2011) supplemented by manual searches of bibliographies. Included were cohort studies and case-control studies assessing biochemical cardiovascular risk factors in women with previous hypertensive pregnancy disorders compared with women with previous normotensive pregnancies. Of 2573 studies reviewed for eligibility, quality, and data extraction, 22 were included in the review, of which 15 could be meta-analyzed. The pooled mean differences for the outcomes of interest were 0.17 mmol/L (95% confidence interval [CI], 0.08–0.25 mmol/L) for glucose (10 studies), 3.46 mU/mL (95% CI, 2.34–4.58 mU/mL) for insulin (5 studies), 0.13 mmol/L (95% CI, 0.05–0.21) for triglycerides (10 studies), 0.22 mmol/L (95% CI, 0.11–0.33 mmol/L) for total cholesterol (11 studies), -0.11 mmol/L (95% CI, -0.18 to -0.04 mmol/L) for high-density lipoprotein cholesterol (10 studies), and 0.21 mmol/L (95% CI, 0.10–0.32) for low-density lipoprotein cholesterol (9 studies), all in the disadvantage in women with previous hypertensive pregnancy disorders. Analyses for preeclampsia alone showed similar results. Continued LEARNING OBJECTIVES: After completing this CME activity, physicians should be better able to assess the long-term cardiovascular consequences after hypertensive pregnancy disorders, evaluate and interpret the evidence regarding biochemical cardiovascular risk factor assessment after pregnancy, and counsel women with a history of hypertensive pregnancy disorders as to the effectiveness of cardiovascular risk factor assessment in the primary prevention of cardiovascular disease. CONCLUSIONS: Women with previous hypertensive pregnancy disorders have higher glucose, insulin, triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels measured after pregnancy compared with women with previous normotensive pregnancies. These biochemical cardiovascular risk factors may identify women who will benefit from primary prevention of cardiovascular disease. TARGET AUDIENCE: Obstetricians and gynecologists, family physicians. |
Keywords: | Humans Albuminuria Hypertension, Pregnancy-Induced Cardiovascular Diseases Cholesterol Insulin Blood Glucose Triglycerides C-Reactive Protein Risk Factors Pregnancy Female Cholesterol, LDL Cholesterol, HDL |
Rights: | Copyright © 2012 Lippincott Williams & Wilkins. |
DOI: | 10.1097/OGX.0b013e31827682fc |
Published version: | http://dx.doi.org/10.1097/ogx.0b013e31827682fc |
Appears in Collections: | Aurora harvest 7 Paediatrics publications |
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