Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/87469
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Type: Journal article
Title: Upregulation of intestinal glucose transporters after Roux-en-Y gastric bypass to prevent carbohydrate malabsorption
Author: Nguyen, N.
Debreceni, T.
Bambrick, J.
Chia, B.
Deane, A.
Wittert, G.
Rayner, C.
Horowitz, M.
Young, R.
Citation: Obesity, 2014; 22(10):2164-2171
Publisher: Wiley
Issue Date: 2014
ISSN: 1930-7381
1930-739X
Statement of
Responsibility: 
Nam Q. Nguyen, Tamara L. Debreceni, Jenna E. Bambrick, Bridgette Chia, Adam M. Deane, Gary Wittert, Chris K. Rayner, Michael Horowitz and Richard L. Young
Abstract: OBJECTIVE: To determine the effect of Roux-en-Y gastric bypass (RYGB) on the expression of intestinal sweet taste receptors (STRs), glucose transporters (GTs), glucose absorption, and glycemia. METHODS: Intestinal biopsies were collected for mRNA expression of STR (T1R2) and GTs (SGLT-1 and GLUT2) from 11 non-diabetic RYGB, 13 non-diabetic obese, and 11 healthy subjects, at baseline and following a 30 min small intestinal (SI) glucose infusion (30 g/150 ml water with 3 g 3-O-methyl-d-glucopyranose (3-OMG)). Blood glucose, plasma 3-OMG, and insulin were measured for 270 min. RESULTS: In RYGB patients, expression of both GTs was ∼2-fold higher at baseline and after glucose infusion than those of morbidly obese or healthy subjects (P < 0.001). STR expressions were comparable amongst the groups. Peak plasma 3-OMG in both RYGB (r = 0.69, P = 0.01) and obese (r = 0.72, P = 0.005) correlated with baseline expression of SGLT-1, as was the case with peak blood glucose in RYGB subjects (r = 0.69, P = 0.02). CONCLUSIONS: The upregulated intestinal GTs in RYGB patients are associated with increased glucose absorption when glucose is delivered at a physiological rate, suggesting a molecular adaptation to prevent carbohydrate malabsorption from rapid intestinal transit after RYGB.
Keywords: Intestines; Humans; Malabsorption Syndromes; Obesity, Morbid; Insulin; Glucose; Blood Glucose; Gastric Bypass; Case-Control Studies; Up-Regulation; Intestinal Absorption; Adult; Middle Aged; Female; Male; Carbohydrate Metabolism; Glucose Transport Proteins, Facilitative
Rights: © 2014 The Obesity Society
RMID: 0030011072
DOI: 10.1002/oby.20829
Appears in Collections:Medicine publications

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