Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/87428
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nguyen, N. | - |
dc.contributor.author | Debreceni, T. | - |
dc.contributor.author | Bambrick, J. | - |
dc.contributor.author | Bellon, M. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Standfield, S. | - |
dc.contributor.author | Rayner, C. | - |
dc.contributor.author | Horowitz, M. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Obesity, 2014; 22(9):2003-2009 | - |
dc.identifier.issn | 1930-7381 | - |
dc.identifier.issn | 1930-739X | - |
dc.identifier.uri | http://hdl.handle.net/2440/87428 | - |
dc.description.abstract | OBJECTIVE: To evaluate the effect of modulating pouch emptying (PE) and SI transit of glucose after Roux-en-Y gastric bypass (RYGB) on blood glucose, incretin hormones, glucose absorption and gastrointestinal (GI) symptoms. METHODS: Ten RYGB patients were studied twice in random order, receiving either a 150 ml glucose drink (200 kcal) or the same solution infused into the proximal Roux-limb at 4 kcal/min. Data were compared with 10 healthy volunteers who received a 4 kcal/min duodenal infusion. PE, cecal arrival time (CAT), blood glucose, plasma 3-O-methylglucose (3-OMG), insulin, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1), and GI symptoms were measured. RESULTS: In RYGB subjects, the glucose drink emptied very rapidly (PE t50 = 3 ± 1 min) and intestinal glucose infusion was associated with higher blood glucose and plasma 3-OMG, but lower plasma GLP-1, GIP, insulin, and GI symptoms than oral glucose (all P < 0.001), and comparable to volunteers. In RYGB subjects, CAT correlated inversely with peak GLP-1 (r = -0.73, P = 0.01), and plasma 3-OMG correlated tightly blood glucose (r = 0.94, P < 0.0001). CONCLUSIONS: After RYGB, reducing intestinal glucose delivery to 4 kcal/min is associated with higher blood glucose, greater glucose absorption, lower incretin responses, and less GI symptoms, supporting rapid transit contribution to the exaggerated incretin responses and "dumping symptoms". | - |
dc.description.statementofresponsibility | Nam Q. Nguyen, Tamara L. Debreceni, Jenna E. Bambrick, Max Bellon, Judith Wishart, Scott Standfield, Chris K. Rayner and Michael Horowitz | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2014 The Obesity Society | - |
dc.source.uri | http://dx.doi.org/10.1002/oby.20791 | - |
dc.subject | Humans | - |
dc.subject | Dumping Syndrome | - |
dc.subject | Gastrointestinal Hormones | - |
dc.subject | Insulin | - |
dc.subject | Glucose | - |
dc.subject | Blood Glucose | - |
dc.subject | Gastrointestinal Transit | - |
dc.subject | Gastric Bypass | - |
dc.subject | Intestinal Absorption | - |
dc.subject | Postprandial Period | - |
dc.subject | Time Factors | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Rapid gastric and intestinal transit is a major determinant of changes in blood glucose, intestinal hormones, glucose absorption and postprandial symptoms after gastric bypass | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/oby.20791 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Nguyen, N. [0000-0002-1270-5441] | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Aurora harvest 2 Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.