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dc.contributor.authorNguyen, N.en
dc.contributor.authorDebreceni, T.en
dc.contributor.authorBambrick, J.en
dc.contributor.authorBellon, M.en
dc.contributor.authorWishart, J.en
dc.contributor.authorStandfield, S.en
dc.contributor.authorRayner, C.en
dc.contributor.authorHorowitz, M.en
dc.identifier.citationObesity, 2014; 22(9):2003-2009en
dc.description.abstractOBJECTIVE: To evaluate the effect of modulating pouch emptying (PE) and SI transit of glucose after Roux-en-Y gastric bypass (RYGB) on blood glucose, incretin hormones, glucose absorption and gastrointestinal (GI) symptoms. METHODS: Ten RYGB patients were studied twice in random order, receiving either a 150 ml glucose drink (200 kcal) or the same solution infused into the proximal Roux-limb at 4 kcal/min. Data were compared with 10 healthy volunteers who received a 4 kcal/min duodenal infusion. PE, cecal arrival time (CAT), blood glucose, plasma 3-O-methylglucose (3-OMG), insulin, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1), and GI symptoms were measured. RESULTS: In RYGB subjects, the glucose drink emptied very rapidly (PE t50 = 3 ± 1 min) and intestinal glucose infusion was associated with higher blood glucose and plasma 3-OMG, but lower plasma GLP-1, GIP, insulin, and GI symptoms than oral glucose (all P < 0.001), and comparable to volunteers. In RYGB subjects, CAT correlated inversely with peak GLP-1 (r = -0.73, P = 0.01), and plasma 3-OMG correlated tightly blood glucose (r = 0.94, P < 0.0001). CONCLUSIONS: After RYGB, reducing intestinal glucose delivery to 4 kcal/min is associated with higher blood glucose, greater glucose absorption, lower incretin responses, and less GI symptoms, supporting rapid transit contribution to the exaggerated incretin responses and "dumping symptoms".en
dc.description.statementofresponsibilityNam Q. Nguyen, Tamara L. Debreceni, Jenna E. Bambrick, Max Bellon, Judith Wishart, Scott Standfield, Chris K. Rayner and Michael Horowitzen
dc.rights© 2014 The Obesity Societyen
dc.subjectHumans; Dumping Syndrome; Gastrointestinal Hormones; Insulin; Glucose; Blood Glucose; Gastrointestinal Transit; Gastric Bypass; Intestinal Absorption; Postprandial Period; Time Factors; Adult; Middle Aged; Female; Maleen
dc.titleRapid gastric and intestinal transit is a major determinant of changes in blood glucose, intestinal hormones, glucose absorption and postprandial symptoms after gastric bypassen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
Appears in Collections:Medicine publications

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