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https://hdl.handle.net/2440/85785
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Type: | Journal article |
Title: | Effect of immunization with pneumolysin on survival time of mice challenged with Streptococcus pneumoniae |
Author: | Paton, J. Lock, R. Hansman, D. |
Citation: | Infection and Immunity, 1983; 40(2):548-552 |
Publisher: | American Society for Microbiology |
Issue Date: | 1983 |
ISSN: | 0019-9567 1098-5522 |
Statement of Responsibility: | James C. Paton, Robert A. Lock, and David J. Hansman |
Abstract: | The role of the cytolytic toxin pneumolysin in the pathogenicity of Streptococcus pneumoniae was investigated. Pneumolysin was purified to homogeneity and used to immunize mice. When these mice were subsequently challenged via the nasal route with virulent S. pneumoniae, they survived significantly longer than control mice. The mean survival times were 5.52 and 2.48 days for immunized and control mice, respectively. This work provides direct evidence for the involvement of pneumolysin in pneumococcal pathogenicity. |
Keywords: | Animals Mice Streptococcus pneumoniae Pneumococcal Infections Bacterial Proteins Streptolysins Antibodies, Bacterial Immunization |
Rights: | © 1983, American Society for Microbiology |
DOI: | 10.1128/iai.40.2.548-552.1983 |
Published version: | http://iai.asm.org/content/40/2/548 |
Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
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