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https://hdl.handle.net/2440/85737
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Type: | Journal article |
Title: | Pneumococcal carriage and type-specific antibody: failure of a 14-valent vaccine to reduce carriage in healthy children |
Author: | Douglas, R.M. Hansman, D. Miles, H.B. Paton, J.C. |
Citation: | American journal of diseases of children (1960), 1986; 140(11):1183-1185 |
Publisher: | American Medical Association |
Issue Date: | 1986 |
ISSN: | 0002-922X 2374-3018 |
Statement of Responsibility: | Robert M. Douglas, David Hansman, Helen B. Miles, James C. Paton |
Abstract: | No consistent effect on nasal carriage rates of Streptococcus pneumoniae belonging to vaccine types was observed during a randomized, controlled trial of a 14-valent pneumococcal vaccine, which included 1273 Australian children aged 6 to 54 months. Nasal carriage of S pneumoniae was associated with a significantly elevated homotypic serum antibody concentration for types 18C, 19F, and 23F, but not for types 6A and 14 (these five types are the most important causes of pneumococcal infections in children). Upper respiratory tract carriage seems to play an important role in natural acquisition of antibody to some but not all pneumococcal serotypes. These findings help to explain why pneumococcal vaccine fails to protect young children from acute otitis media. |
Keywords: | Nose Humans Streptococcus pneumoniae Bacterial Vaccines Pneumococcal Vaccines Antibodies, Bacterial Serotyping Double-Blind Method Random Allocation Child, Preschool Infant Clinical Trials as Topic |
Rights: | Copyright status unknown |
DOI: | 10.1001/archpedi.1986.02140250109044 |
Published version: | http://dx.doi.org/10.1001/archpedi.1986.02140250109044 |
Appears in Collections: | Aurora harvest 7 Molecular and Biomedical Science publications |
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