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https://hdl.handle.net/2440/85260
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Type: | Journal article |
Title: | Granulocyte-macrophage colony stimulating factor (GM-CSF): one of a family of epithelial cell-derived cytokines in the preimplantation uterus |
Author: | Robertson, S.A. Seamark, R.F. |
Citation: | Reproduction Fertility and Development, 1992; 4(4):435-448 |
Publisher: | CSIRO Publishing |
Issue Date: | 1992 |
ISSN: | 1031-3613 1448-5990 |
Statement of Responsibility: | SA Robertson and RF Seamark |
Abstract: | Granulocyte-macrophage colony stimulating factor (GM-CSF) is one of a number of lympho-haemapoietic cytokines, including CSF-1, interleukin-6 (IL-6) and leukaemia inhibitory factor (LIF) now known to be synthesized by epithelial cells in the murine uterus. GM-CSF synthesis is regulated primarily by the ovarian steroid hormone oestrogen, but is also subject to modulation by factors including a seminal component of seminal vesicle origin which stimulates a 20-fold increase in luminal fluid content at mating, and bacterial lipopolysaccharide (LPS) and the T-lymphocyte and natural killer (NK) cell product interferon-gamma (IFN gamma). In the non-pregnant mouse GM-CSF synthesis peaks at oestrus. Synthesis is maintained at comparable or moderately higher levels during the preimplantation period of pregnancy and in the non-decidualized endometrium during mid gestation. An embryotrophic activity is suggested by studies in vitro that indicate that GM-CSF stimulates attachment and outgrowth of blastocysts. It is postulated that GM-CSF is of major importance to the physiology of pregnancy through its role as a component of a local cytokine circuit acting to recruit and regulate function of endometrial leukocytes, and by its action as interlocutor and important effector arm in embryo-maternal interactions during gestation. |
Keywords: | Uterus Leukocytes Animals Humans Steroids Granulocyte-Macrophage Colony-Stimulating Factor Cytokines Embryonic and Fetal Development Embryonic Development Pregnancy Female In Vitro Techniques |
Rights: | © CSIRO 1992 |
DOI: | 10.1071/RD9920435 |
Published version: | http://dx.doi.org/10.1071/rd9920435 |
Appears in Collections: | Aurora harvest 2 Obstetrics and Gynaecology publications |
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