Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/84607
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Type: Journal article
Title: Chemokines and chemokine receptors in mood disorders, schizophrenia, and cognitive impairment: A systematic review of biomarker studies
Author: Stuart, M.
Baune, B.
Citation: Neuroscience and Biobehavioral Reviews, 2014; 42:93-115
Publisher: Pergamon-Elsevier Science
Issue Date: 2014
ISSN: 0149-7634
1873-7528
Statement of
Responsibility: 
M.J. Stuart, B.T.Baune
Abstract: The search for immune biomarkers in psychiatric disorders has primarily focused on pro-inflammatory cytokines. Other immune proteins including chemokines have been relatively neglected in such studies. Recent evidence has implicated chemokines in many neurobiological processes potentially relevant to psychiatric disorders, beyond their classical chemotactic functions. These may include neuromodulator effects, neurotransmitter-like effects, and direct/indirect regulation of neurogenesis. This systematic review presents the existing early evidence which supports an association of many chemokines with the psychiatric disorders: depression, bipolar disorder, schizophrenia, mild cognitive impairment and Alzheimer's disease. The non-specific association of chemokines including CXCL8 (IL-8), CCL2 (MCP-1), CCL3 (MIP-1α) and CCL5 (RANTES) with these disorders across diagnostic categories implies a generalised involvement of many chemokine systemic with psychiatric disease. Additional chemokines with great mechanistic relevance including CXCL12 (SDF-1) and CX3CL1 (fractalkine) have been rarely reported in the existing human literature and should be included in future clinical studies. The potential utility of these proteins as pathologically relevant biomarkers or therapeutic targets should be considered by future clinical and translational research.
Keywords: Chemokine; Cytokine; Immune; Cognition; Depression; Alzheimer’s; Bipolar; Schizophrenia; Suicide; Hippocampus; Biomarker
Rights: © 2014 Elsevier Ltd. All rights reserved.
RMID: 0020138820
DOI: 10.1016/j.neubiorev.2014.02.001
Appears in Collections:Psychiatry publications

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