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Type: Journal article
Title: High-density mapping of ventricular scar a comparison of ventricular tachycardia (VT) supporting channels with channels that do not support VT
Author: Nayyar, S.
Wilson, L.
Ganesan, A.
Sullivan, T.
Kuklik, P.
Chapman, D.
Brooks, A.
Mahajan, R.
Baumert, M.
Young, G.
Sanders, P.
Roberts-Thomson, K.
Citation: Circulation, Arrhythmia & Electrophysiology, 2014; 7(1):90-98
Publisher: Lippincott Williams & Wilkins
Issue Date: 2014
ISSN: 1941-3149
Statement of
Sachin Nayyar, Lauren Wilson, Anand N. Ganesan, Thomas Sullivan, Pawel Kuklik, Darius Chapman, Anthony G. Brooks, Rajiv Mahajan, Mathias Baumert, Glenn D. Young, Prashanthan Sanders, Kurt C. Roberts-Thomson
Abstract: Background—Surviving myocytes within scar may form channels that support ventricular tachycardia (VT) circuits. There are little data on the properties of channels that comprise VT circuits and those that are non-VT supporting channels. Methods and Results—In 22 patients with ischemic cardiomyopathy and VT, high-density mapping was performed with the PentaRay catheter and Ensite NavX system during sinus rhythm. A channel was defined as a series of matching pacemaps with a stimulus (S) to QRS time of ≥40 ms. Sites were determined to be part of a VT channel if there were matching pace-maps to the VT morphology. This was confirmed with entrainment mapping when possible. Of the 238 channels identified, 57 channels corresponded to an inducible VT. Channels that were part of a VT circuit were more commonly located within dense scar than non-VT channels (97% versus 82%; P=0.036). VT supporting channels were of greater length (mean±SEM, 53±5 versus 33±4 mm), had higher longest S-QRS (130±12 versus 82±12 ms), longer conduction time (103±14 versus 43±13 ms), and slower conduction velocity (0.87±0.23 versus 1.39±0.21 m/s) than non-VT channels (P<0.001). Of all the fractionated, late, and very late potentials located in scar, only 21%, 26%, and 29%, respectively, were recorded within VT channels. Conclusions—High-density mapping shows substantial differences among channels in ventricular scar. Channels supporting VT are more commonly located in dense scar, longer than non-VT channels, and have slower conduction velocity. Only a minority of scar-related potentials participate in the VT supporting channels.
Keywords: Catheter ablation; ischemic cardiomyopathy; substrate ablation; tachycardia, ventricular
Rights: © 2014 American Heart Association, Inc.
RMID: 0020138828
DOI: 10.1161/CIRCEP.113.000882
Appears in Collections:Medicine publications

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