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Type: Journal article
Title: Comparative effects of prolonged and intermittent stimulation of the glucagon- like peptide 1 receptor on gastric emptying and glycemia
Author: Umapathysivam, M.
Lee, M.
Jones, K.
Annink, C.
Cousins, C.
Trahair, L.
Rayner, C.
Chapman, M.
Nauck, M.
Horowitz, M.
Deane, A.
Citation: Diabetes, 2014; 63(2):785-790
Publisher: American Diabetes Association
Issue Date: 2014
ISSN: 0012-1797
Statement of
Mahesh M. Umapathysivam, Michael Y. Lee, Karen L. Jones,Christopher E. Annink, Caroline E. Cousins, Laurence G. Trahair, Chris K. Rayner, Marianne J. Chapman, Michael A. Nauck, Michael Horowitz, and Adam M. Deane
Abstract: Acute administration of glucagon-like peptide 1 (GLP-1) and its agonists slows gastric emptying, which represents the major mechanism underlying their attenuation of postprandial glycemic excursions. However, this effect may diminish during prolonged use. We compared the effects of prolonged and intermittent stimulation of the GLP-1 receptor on gastric emptying and glycemia. Ten healthy men received intravenous saline (placebo) or GLP-1 (0.8 pmol/kg $ min), as a continuous 24-h infusion (“prolonged”), two 4.5-h infusions separated by 20 h (“intermittent”), and a 4.5-h infusion (“acute”) in a randomized, double-blind, crossover fashion. Gastric emptying of a radiolabeled mashed potato meal was measured using scintigraphy. Acute GLP-1 markedly slowed gastric emptying. The magnitude of the slowing was attenuated with prolonged but maintained with intermittent infusions. GLP-1 potently diminished postprandial glycemia during acute and intermittent regimens. These observations suggest that short-acting GLP-1 agonists may be superior to long-acting agonists when aiming specifically to reduce postprandial glycemic excursions in the treatment of type 2 diabetes.
Keywords: Humans
Blood Glucose
Receptors, Glucagon
Area Under Curve
Cross-Over Studies
Double-Blind Method
Gastric Emptying
Glucagon-Like Peptide 1
Young Adult
Glucagon-Like Peptide-1 Receptor
Rights: © 2014 by the American Diabetes Association
DOI: 10.2337/db13-0893
Appears in Collections:Anaesthesia and Intensive Care publications
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