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|Title:||Placental restriction of fetal growth reduces cutaneous responses to antigen after sensitization in sheep|
|Citation:||American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 2014; 306(7):R441-R446|
|Publisher:||American Physiological Society|
|Amy L. Wooldridge, Robert J. Bischof, Els N. Meeusen, Hong Liu, Gary K. Heinemann, Damien S. Hunter, Lynne C. Giles, Karen L. Kind, Julie A. Owens, Vicki L. Clifton, Kathryn L. Gatford|
|Abstract:||Prenatal and early childhood exposures are implicated as causes of allergy, but the effects of intrauterine growth restriction on immune function and allergy are poorly defined. We therefore evaluated effects of experimental restriction of fetal growth on immune function and allergic sensitization in adolescent sheep. Immune function (circulating total red and white blood cells, neutrophils, lymphocytes, monocytes, eosinophils and basophils, and the antibody response to Clostridial vaccination) and responses to house dust mite (HDM) allergen and ovalbumin (OVA) antigen sensitization (specific total Ig, IgG1 and IgE antibodies, and cutaneous hypersensitivity) were investigated in adolescent sheep from placentally-restricted (PR, n = 23) and control (n = 40) pregnancies. Increases in circulating HDM-specific IgE (P = 0.007) and OVA-specific IgE (P = 0.038) were greater in PR than control progeny. PR did not alter total Ig, IgG1 or IgM responses to either antigen. PR increased OVA-specific but not HDM-specific IgA responses in females only (P = 0.023). Multiple birth increased Ig responses to OVA in a sex-specific manner. PR decreased the proportion of positive cutaneous hypersensitivity responders to OVA at 24 h (P = 0.030), but had no effect on cutaneous responses to HDM. Acute wheal responses to intradermal histamine correlated positively with birth weight in singletons (P = 0.023). Intrauterine growth restriction may suppress inflammatory responses in skin downstream of IgE induction, without impairment in antibody responses to a non-polysaccharide vaccine. Discord between cutaneous and IgE responses following sensitization suggests new mechanisms for prenatal allergy programming.|
Fetal Growth Retardation
Disease Models, Animal
|Rights:||Copyright © 2014 by the American Physiological Society.|
|Appears in Collections:||Aurora harvest 4|
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