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dc.contributor.authorChappell, L.-
dc.contributor.authorSeed, P.-
dc.contributor.authorMyers, J.-
dc.contributor.authorTaylor, R.-
dc.contributor.authorKenny, L.-
dc.contributor.authorDekker, G.-
dc.contributor.authorWalker, J.-
dc.contributor.authorMcCowan, L.-
dc.contributor.authorNorth, R.-
dc.contributor.authorPoston, L.-
dc.identifier.citationBMJ: British Medical Journal, 2013; 347(nov21 3):1-13-
dc.description.abstractObjective: To identify factors at 15 and 20 weeks’ gestation associated with a subsequent uncomplicated pregnancy. Design: Prospective international multicentre observational cohort study. Setting: Auckland, New Zealand and Adelaide, Australia (exploration and local replication dataset) and Manchester, Leeds, and London, United Kingdom, and Cork, Republic of Ireland (external confirmation dataset). Participants: 5628 healthy nulliparous women with a singleton pregnancy. Main outcome measure: Uncomplicated pregnancy, defined as a normotensive pregnancy delivered at >37 weeks’ gestation, resulting in a liveborn baby not small for gestational age, and the absence of any other significant pregnancy complications. In a stepwise logistic regression the comparison group was women with a complicated pregnancy. Results: Of the 5628 women, 3452 (61.3%) had an uncomplicated pregnancy. Factors that reduced the likelihood of an uncomplicated pregnancy included increased body mass index (relative risk 0.74, 95% confidence intervals 0.65 to 0.84), misuse of drugs in the first trimester (0.90, 0.84 to 0.97), mean diastolic blood pressure (for each 5 mm Hg increase 0.92, 0.91 to 0.94), and mean systolic blood pressure (for each 5 mm Hg increase 0.95, 0.94 to 0.96). Beneficial factors were prepregnancy fruit intake at least three times daily (1.09, 1.01 to 1.18) and being in paid employment (per eight hours’ increase 1.02, 1.01 to 1.04). Detrimental factors not amenable to alteration were a history of hypertension while using oral contraception, socioeconomic index, family history of any hypertensive complications in pregnancy, vaginal bleeding during pregnancy, and increasing uterine artery resistance index. Smoking in pregnancy was noted to be a detrimental factor in the initial two datasets but did not remain in the final model. Conclusions: This study identified factors associated with normal pregnancy through adoption of a novel hypothesis generating approach, which has shifted the emphasis away from adverse outcomes towards uncomplicated pregnancies. Although confirmation in other cohorts is necessary, this study implies that individually targeted lifestyle interventions (normalising maternal weight, increasing prepregnancy fruit intake, reducing blood pressure, stopping misuse of drugs) may increase the likelihood of normal pregnancy outcomes.-
dc.description.statementofresponsibilityLucy C Chappell, Paul T Seed, Jenny Myers, Rennae S Taylor, Louise C Kenny, Gustaaf A Dekker, James J Walker, Lesley M E McCowan, Robyn A North, Lucilla Poston-
dc.publisherBMJ Publishing Group-
dc.rightsThis is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
dc.subjectPregnancy Complications-
dc.subjectPregnancy Complications, Cardiovascular-
dc.subjectVascular Diseases-
dc.subjectBody Mass Index-
dc.subjectPregnancy Outcome-
dc.subjectLogistic Models-
dc.subjectRisk Factors-
dc.subjectCohort Studies-
dc.subjectProspective Studies-
dc.subjectBlood Pressure-
dc.subjectVascular Resistance-
dc.subjectSocioeconomic Factors-
dc.subjectNew Zealand-
dc.subjectYoung Adult-
dc.subjectUterine Artery-
dc.subjectUnited Kingdom-
dc.titleExploration and confirmation of factors associated with uncomplicated pregnancy in nulliparous women: prospective cohort study-
dc.typeJournal article-
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]-
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Obstetrics and Gynaecology publications

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