Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/81896
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Type: Journal article
Title: Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease
Author: Weekley, C.
Harris, H.
Citation: Chemical Society Reviews, 2013; 42(23):8870-8894
Publisher: Royal Soc Chemistry
Issue Date: 2013
ISSN: 0306-0012
1460-4744
Statement of
Responsibility: 
Claire M. Weekley and Hugh H. Harris
Abstract: The biological activity of selenium is dependent upon its speciation. We aim to integrate selenium speciation and metabolism into a discussion of the mechanisms by which selenium exerts its biological activity. First, we present the current status of selenium in the prevention of cancer, cardiovascular and neurodegenerative diseases with particular attention paid to the results of major chemoprevention trials involving selenium supplementation. A comprehensive review of the current understanding of the metabolism of common dietary selenium compounds - selenite, selenomethionine, methylselenocysteine and selenocystine - is presented, with discussion of the evidence for the various metabolic pathways and their products. The antioxidant, prooxidant and other mechanisms of the dietary selenium compounds have been linked to their disease prevention and treatment properties. The evidence for these various mechanisms -in vitro, in cells and in vivo- is evaluated with emphasis on the selenium metabolites involved. We conclude that dietary selenium compounds should be considered prodrugs, whose biological activity will depend on the activity of the various metabolic pathways in, and the redox status of, cells and tissues. These factors should be considered in future laboratory research and in selecting selenium compounds for trials of disease prevention and treatment by selenium supplementation.
Keywords: Humans
Neoplasms
Cystine
Reactive Oxygen Species
Selenium Compounds
Organoselenium Compounds
Selenocysteine
Selenomethionine
Sulfhydryl Compounds
Dietary Supplements
Selenoproteins
Clinical Trials as Topic
Histone Deacetylase Inhibitors
Rights: © The Royal Society of Chemistry 2013
DOI: 10.1039/c3cs60272a
Grant ID: http://purl.org/au-research/grants/arc/DP0985807
Published version: http://dx.doi.org/10.1039/c3cs60272a
Appears in Collections:Aurora harvest 4
Chemistry and Physics publications

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