Adelaide Research & Scholarship
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https://hdl.handle.net/2440/81644
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| Type: | Journal article |
| Title: | Biomimetic total synthesis of (±)-merochlorin A |
| Other Titles: | Biomimetic total synthesis of (+)-merochlorin A |
| Author: | Pepper, H. George, J. |
| Citation: | Angewandte Chemie International Edition, 2013; 52(46):12170-12173 |
| Publisher: | Wiley-V C H Verlag GMBH |
| Issue Date: | 2013 |
| ISSN: | 1433-7851 1521-3773 |
| Statement of Responsibility: | Henry P. Pepper and Jonathan H. George |
| Abstract: | Inspired: The proposed biosynthetic pathway toward the potent antibiotic meroterpenoid (±)-merochlorinA inspired its concise total synthesis. The key steps in the synthesis are a one-pot aromatization-alkylation reaction, followed by a biomimetic oxidative dearomatization of a highly functionalized naphthalene derivative, which forms two rings and four contiguous stereocenters in a single step. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| Keywords: | antibiotics biomimetic synthesis cascade reactions natural products |
| Rights: | Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
| DOI: | 10.1002/anie.201307200 |
| Grant ID: | http://purl.org/au-research/grants/arc/DE130100689 http://purl.org/au-research/grants/arc/DE130100689 |
| Published version: | http://dx.doi.org/10.1002/anie.201307200 |
| Appears in Collections: | Aurora harvest 4 Chemistry and Physics publications |
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