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Type: Journal article
Title: Modulation of individual components of gastric motor response to duodenal glucose
Author: Deane, A.
Besanko, L.
Burgstad, C.
Chapman, M.
Horowitz, M.
Fraser, R.
Citation: World Journal of Gastroenterology, 2013; 19(35):5863-5869
Publisher: W J G Press
Issue Date: 2013
ISSN: 1007-9327
Statement of
Adam M Deane, Laura K Besanko, Carly M Burgstad, Marianne J Chapman, Michael Horowitz, Robert JL Fraser
Abstract: AIM: To evaluate individual components of the antro-pyloro-duodenal (APD) motor response to graded small intestinal glucose infusions in healthy humans. METHODS: APD manometry was performed in 15 healthy subjects (12 male; 40 ± 5 years, body mass index 26.5 ± 1.6 kg/m2) during four 20-min intraduodenal infusions of glucose at 0, 0.5, 1.0 and 1.5 kcal/min, in a randomised double-blinded fashion. Glucose solutions were infused at a rate of 1 mL/min and separated by 40-min “wash-out” period. Data are mean ± SE. Inferential analyses are repeated measure analysis of variance with Bonferroni post-hoc testing. RESULTS: At 0 kcal/min frequency of pressure waves were: antrum (7.5 ± 1.8 waves/20 min) and isolated pyloric pressure waves (IPPWs) (8.0 ± 2.3 waves/20 min) with pyloric tone (0.0 ± 0.9 mmHg). Intraduodenal glucose infusion acutely increased IPPW frequency (P < 0.001) and pyloric tone (P = 0.015), and decreased antral wave frequency (P = 0.007) in a dose-dependent fashion. A threshold for stimulation was observed at 1.0 kcal/min for pyloric phasic pressure waves (P = 0.002) and 1.5 kcal/min for pyloric tone and antral contractility. CONCLUSION: There is hierarchy for the activation of gastrointestinal motor responses to duodenal glucose infusion. An increase in IPPWs is the first response observed.
Keywords: Glucose
Gastrointestinal motility
Motor activity
Blood glucose
Rights: ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
DOI: 10.3748/wjg.v19.i35.5863
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