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https://hdl.handle.net/2440/81371
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Type: | Journal article |
Title: | Macrophage inhibitory cytokine-1 is associated with cognitive impairment and predicts cognitive decline - the Sydney memory and aging study |
Author: | Fuchs, T. Trollor, J. Crawford, J. Brown, D. Baune, B. Samaras, K. Campbell, L. Breit, S. Brodaty, H. Sachdev, P. Smith, E. |
Citation: | Aging Cell, 2013; 12(5):882-889 |
Publisher: | Wiley-Blackwell Publishing Ltd |
Issue Date: | 2013 |
ISSN: | 1474-9718 1474-9726 |
Statement of Responsibility: | Talia Fuchs, Julian N. Trollor, John Crawford, David A. Brown, Bernhard T. Baune, Katherine Samaras, Lesley Campbell, Samuel N. Breit, Henry Brodaty, Perminder Sachdev, and Evelyn Smith |
Abstract: | Higher levels of macrophage inhibitory cytokine-1, also known as growth differentiation factor 15 (MIC-1/GDF15), are associated with adverse health outcomes and all-cause mortality. The aim of this study was to examine the relationships between MIC-1/GDF15 serum levels and global cognition, five cognitive domains, and mild cognitive impairment (MCI), at baseline (Wave 1) and prospectively at 2 years (Wave 2), in nondemented participants aged 70-90 years. Analyses were controlled for age, sex, education, Framingham risk score, history of cerebrovascular accident, acute myocardial infarction, angina, cancer, depression, C-reactive protein, tumor necrosis factor-α, interleukins 6 and 12, and apolipoprotein ε4 genotype. Higher MIC-1/GDF15 levels were significantly associated with lower global cognition at both waves. Cross-sectional associations were found between MIC-1/GDF15 and all cognitive domains in Wave 1 (all P < 0.001) and between processing speed, memory, and executive function in Wave 2 (all P < 0.001). Only a trend was found for the prospective analyses, individuals with high MIC-1/GDF15 at baseline declined in global cognition, executive function, memory, and processing speed. However, when categorizing MIC-1/GDF15 by tertiles, prospective analyses revealed statistically significant lower memory and executive function in Wave 2 in those in the upper tertile compared with the lower tertile. Receiver operating characteristics (ROC) analysis was used to determine MIC-1/GDF15 cutoff values associated with cognitive decline and showed that a MIC-1/GDF15 level exceeding 2764 pg/ml was associated with a 20% chance of decline from normal to MCI or dementia. In summary, MIC-1/GDF15 levels are associated with cognitive performance and cognitive decline. Further research is required to determine the pathophysiology of this relationship. |
Keywords: | aging cognitive decline dementia growth differentiation factor-15 inflammation macrophage inhibitory cytokine-1 mild cognitive impairment |
Rights: | © 2013 The Anatomical Society and John Wiley & Sons Ltd |
DOI: | 10.1111/acel.12116 |
Published version: | http://dx.doi.org/10.1111/acel.12116 |
Appears in Collections: | Aurora harvest 4 Psychiatry publications |
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