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https://hdl.handle.net/2440/78444
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Type: | Journal article |
Title: | Multiplexing of radiative-surface plasmon resonance for the detection of gastric cancer biomarkers in a single optical fiber |
Author: | Sciacca, B. François, A. Hoffmann, P. Monro, T. |
Citation: | Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers, 2013; 183:454-458 |
Publisher: | Elsevier Science SA |
Issue Date: | 2013 |
ISSN: | 0925-4005 0925-4005 |
Statement of Responsibility: | Beniamino Sciacca, Alexandre François, Peter Hoffmann, Tanya M. Monro |
Abstract: | The simultaneous detection of multiple biological analytes is achieved for the first time using a single optical fiber based surface plasmon resonance (SPR) biosensor. This is achieved by collecting the plasmonic wave re-scattered by a rough metallic coating deposited onto two separate sections (sensing regions) of a single multimode optical fiber. The results obtained showed that two gastric cancer biomarkers (apolipoprotein E and clusterin) are detected in clinically relevant concentrations each on a separate sensing region, simultaneously, something that cannot be done in traditional fiber based SPR biosensors that read the transmitted or reflected light to monitor the position of the resonance. While this multiplexing demonstration has been performed with two different biomarkers, it paves the way for the multiplexed detection of a larger number of biomarkers using a simple fiber optic based SPR sensor for point of decision diagnostics. © 2013 Elsevier B.V. |
Keywords: | Surface plasmon resonance Biosensor Multiplexing Clusterin Apolipoprotein E Gastric cancer |
Rights: | Copyright © 2013 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.snb.2013.03.131 |
Published version: | http://dx.doi.org/10.1016/j.snb.2013.03.131 |
Appears in Collections: | Aurora harvest 4 IPAS publications |
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