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https://hdl.handle.net/2440/76296
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dc.contributor.author | Uher, R. | - |
dc.contributor.author | Perroud, N. | - |
dc.contributor.author | Ng, M. | - |
dc.contributor.author | Hauser, J. | - |
dc.contributor.author | Henigsberg, N. | - |
dc.contributor.author | Maier, W. | - |
dc.contributor.author | Mors, O. | - |
dc.contributor.author | Placentino, A. | - |
dc.contributor.author | Rietschel, M. | - |
dc.contributor.author | Souery, D. | - |
dc.contributor.author | Zagar, T. | - |
dc.contributor.author | Czerski, P. | - |
dc.contributor.author | Jerman, B. | - |
dc.contributor.author | Larsen, E. | - |
dc.contributor.author | Schulze, T. | - |
dc.contributor.author | Zobel, A. | - |
dc.contributor.author | Cohen-Woods, S. | - |
dc.contributor.author | Pirlo, K. | - |
dc.contributor.author | Butler, A. | - |
dc.contributor.author | Muglia, P. | - |
dc.contributor.author | et al. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | American Journal of Psychiatry, 2010; 167(5):555-564 | - |
dc.identifier.issn | 0002-953X | - |
dc.identifier.issn | 1535-7228 | - |
dc.identifier.uri | http://hdl.handle.net/2440/76296 | - |
dc.description.abstract | <h4>Objective</h4>The purpose of this study was to identify genetic variants underlying the considerable individual differences in response to antidepressant treatment. The authors performed a genome-wide association analysis of improvement of depression severity with two antidepressant drugs.<h4>Method</h4>High-quality Illumina Human610-quad chip genotyping data were available for 706 unrelated participants of European ancestry treated for major depression with escitalopram (N=394) or nortriptyline (N=312) over a 12-week period in the Genome-Based Therapeutic Drugs for Depression (GENDEP) project, a partially randomized open-label pharmacogenetic trial.<h4>Results</h4>Single nucleotide polymorphisms in two intergenic regions containing copy number variants on chromosomes 1 and 10 were associated with the outcome of treatment with escitalopram or nortriptyline at suggestive levels of significance and with a high posterior likelihood of true association. Drug-specific analyses revealed a genome-wide significant association between marker rs2500535 in the uronyl 2-sulphotransferase gene and response to nortriptyline. Response to escitalopram was best predicted by a marker in the interleukin-11 (IL11) gene. A set of 72 a priori-selected candidate genes did not show pharmacogenetic associations above a chance level, but an association with response to escitalopram was detected in the interleukin-6 gene, which is a close homologue of IL11.<h4>Conclusions</h4>While limited statistical power means that a number of true associations may have been missed, these results suggest that efficacy of antidepressants may be predicted by genetic markers other than traditional candidates. Genome-wide studies, if properly replicated, may thus be important steps in the elucidation of the genetic basis of pharmacological response. | - |
dc.description.statementofresponsibility | Rudolf Uher... Sarah Cohen-Woods... et al. | - |
dc.language.iso | en | - |
dc.publisher | Amer Psychiatric Press Inc | - |
dc.rights | Copyright © American Psychiatric Association | - |
dc.source.uri | http://dx.doi.org/10.1176/appi.ajp.2009.09070932 | - |
dc.subject | Humans | - |
dc.subject | Citalopram | - |
dc.subject | Nortriptyline | - |
dc.subject | Sulfotransferases | - |
dc.subject | Antidepressive Agents | - |
dc.subject | Antidepressive Agents, Second-Generation | - |
dc.subject | Interleukin-6 | - |
dc.subject | Interleukin-11 | - |
dc.subject | Treatment Outcome | - |
dc.subject | Oligonucleotide Array Sequence Analysis | - |
dc.subject | Depressive Disorder | - |
dc.subject | Depressive Disorder, Major | - |
dc.subject | Psychiatric Status Rating Scales | - |
dc.subject | Pharmacogenetics | - |
dc.subject | Genotype | - |
dc.subject | Phenotype | - |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.subject | Genome-Wide Association Study | - |
dc.title | Genome-wide pharmacogenetics of antidepressant response in the GENDEP project | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1176/appi.ajp.2009.09070932 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Cohen-Woods, S. [0000-0003-2199-6129] | - |
Appears in Collections: | Aurora harvest Psychiatry publications |
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