Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/76270
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Type: Journal article
Title: Methylenetetrahydrofolate reductase gene variant (MTHFR C677T) and migraine: a case control study and meta-analysis
Author: Samaan, Z.
Gaysina, D.
Cohen-Woods, S.
Craddock, N.
Jones, L.
Korszun, A.
Owen, M.
Mente, A.
McGuffin, P.
Farmer, A.
Citation: BMC Neurology, 2011; 11(1):66-1-66-9
Publisher: BioMed Central Ltd.
Issue Date: 2011
ISSN: 1471-2377
1471-2377
Statement of
Responsibility: 
Zainab Samaan, Daria Gaysina, Sarah Cohen-Woods, Nick Craddock, Lisa Jones, Ania Korszun, Mike Owen, Andrew Mente, Peter McGuffin and Anne Farmer
Abstract: Background: Migraine is a common disorder that often coexists with depression. While a functional polymorphism in methyleneterahydrofolate reductase gene (MTHFR C677T) has been implicated in depression; the evidence to support an association of MTHFR with migraine has been inconclusive. We aim to investigate the effect of this variant on propensity for migraine and to perform a systematic review and meta-analysis of studies of MTHFR and migraine to date. Methods: Individuals with migraine (n = 447) were selected from the Depression Case Control (DeCC) study to investigate the association between migraine and MTHFR C677T single nucleotide polymorphism (SNP) rs1801133 using an additive model compared to non-migraineurs adjusting for depression status. A meta-analysis was performed and included 15 studies of MTHFR and migraine. Results: MTHFR C677T polymorphism was associated with migraine with aura (MA) (OR 1.31, 95% CI 1.01-1.70, p = 0.039) that remained significant after adjusting for age, sex and depression status. A meta-analysis of 15 case-control studies showed that T allele homozygosity is significantly associated with MA (OR = 1.42; 95% CI, 1.10-1.82) and total migraine (OR = 1.37; 95% CI, 1.07-1.76), but not migraine without aura (OR = 1.16; 95% CI, 0.36-3.76). In studies of non-Caucasian population, the TT genotype was associated with total migraine (OR= 3.46; 95% CI, 1.22-9.82), whereas in studies of Caucasians this variant was associated with MA only (OR = 1.28; 95% CI, 1.002-1.63). Conclusions: MTHFR C677T is associated with MA in individuals selected for depression study. A meta-analysis of 15 studies supports this association and demonstrated effects across ethnic groups.
Keywords: Humans; Genetic Predisposition to Disease; Carbon-Nitrogen Ligases; Logistic Models; Case-Control Studies; DNA Mutational Analysis; Depression; Psychiatric Status Rating Scales; Gene Frequency; Genotype; Polymorphism, Single Nucleotide; Adult; Middle Aged; Female; Male; Migraine with Aura; Meta-Analysis as Topic
Description: Extent: 9p.
Rights: © 2011 Samaan et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RMID: 0020124230
DOI: 10.1186/1471-2377-11-66
Appears in Collections:Psychiatry publications

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