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https://hdl.handle.net/2440/7616
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Type: | Journal article |
Title: | Relation between pancreatic lipase activity and gastric emptying rate in children with cystic fibrosis |
Author: | Symonds, E. Omari, T. Webster, J. Davidson, G. Butler, R. |
Citation: | Journal of Pediatrics, 2003; 143(6):772-775 |
Publisher: | Mosby Inc |
Issue Date: | 2003 |
ISSN: | 0022-3476 1097-6833 |
Statement of Responsibility: | Symonds, Erin L ; Omari, Taher I ; Webster, Judy M ; Davidson, Geoffrey P ; Butler, Ross N |
Abstract: | <h4>Objective</h4>To determine whether abnormal gastric emptying is responsible for the inability of pancreatic enzyme replacement therapy (PERT) to normalize fat digestion in patients with cystic fibrosis (CF) who are pancreatic-insufficient. Study design Gastric emptying of a solid meal and pancreatic lipase function were assessed in 10 children with CF and 12 healthy control subjects with noninvasive breath tests using (13)C-octanoic acid and (13)C-mixed triglyceride, respectively. Lipase function was assessed in the subjects with CF with and without PERT.<h4>Results</h4>Without PERT, the lipase activity for the patients was less than that for the control subjects (P<.001); however, with PERT, 40% of the patients had a normalized lipase function. There were no differences between the mean gastric emptying rates of the patients with CF and the control subjects (P>.05), but there was a negative correlation between gastric half emptying time and percentage improvement in (13)C-mixed triglyceride results of the patients with CF with pancreatic enzymes compared with placebo (P<.05), with patients with slow gastric emptying having less improvement with PERT.<h4>Conclusions</h4>The success of PERT in improving pancreatic lipase activity is reduced in patients with slow gastric emptying, which could explain the variations in improvement of fat digestion with enzyme supplementation. |
Keywords: | Pancreas Humans Cystic Fibrosis Caprylates Lipase Dietary Fats Triglycerides Breath Tests Digestion Gastric Emptying Adolescent Child Female Male |
DOI: | 10.1067/S0022-3476(03)00581-X |
Published version: | http://dx.doi.org/10.1067/s0022-3476(03)00581-x |
Appears in Collections: | Aurora harvest Paediatrics publications |
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