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Type: Journal article
Title: KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence
Author: Morris, C.
Baune, B.
Domschke, K.
Arolt, V.
Swagell, C.
Hughes, I.
Lawford, B.
Young, R.
Voisey, J.
Citation: Disease Markers, 2012; 33(4):163-170
Publisher: IOS Press
Issue Date: 2012
ISSN: 0278-0240
Statement of
Charles P. Morris, Bernhard T. Baune, Katharina Domschke, Volker Arolt, Christopher D. Swagell, Ian P. Hughes, Bruce R. Lawford, Ross McD Young and Joanne Voisey
Abstract: KPNA3 is a gene that has been linked to schizophrenia susceptibility. In this study we investigated the possible association between KPNA3 variation and schizophrenia. To investigate a wider role of KPNA3 across psychiatric disorders we also analysed major depression, PTSD, nicotine dependent, alcohol dependent and opiate dependent cohorts. Using a haplotype block-based gene-tagging approach we genotyped six KPNA3 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. One SNP rs2273816 was found to be significantly associated with schizophrenia, opiate dependence and alcohol dependence at the genotype and allele level. Major depression was also associated with rs2273816 but only at the allele level. Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders.
Keywords: KPNA3; genetic; schizophrenia; polymorphism; psychiatric disorder; cross-disorder
Rights: © 2012 – IOS Press and the authors. All rights reserved
RMID: 0020123307
DOI: 10.3233/DMA-2012-0921
Appears in Collections:Psychiatry publications

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