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https://hdl.handle.net/2440/72379
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Type: | Journal article |
Title: | Dietary omega-3 supplementation exacerbates left ventricular dysfunction in an ovine model of anthracycline-induced cardiotoxicity |
Author: | Carbone, A. Psaltis, P. Nelson, A. Metcalf, R. Richardson, J. Weightman, M. Thomas, A. Finnie, J. Young, G. Worthley, S. |
Citation: | Journal of Cardiac Failure, 2012; 18(6):502-511 |
Publisher: | Churchill Livingstone Inc Medical Publishers |
Issue Date: | 2012 |
ISSN: | 1071-9164 1532-8414 |
Statement of Responsibility: | Angelo Carbone, Peter J. Psaltis, Adam J. Nelson, Robert Metcalf, James D. Richardson, Michael Weightman, Anthony Thomas, John W. Finnie, Glenn D. Young and Stephen G. Worthley |
Abstract: | BACKGROUND: Cumulative dose-dependent nonischemic cardiomyopathy (NICM) remains a significant risk with the use of some chemotherapeutic agents. In this context, omega-3 polyunsaturated fatty acids (PUFA) have been investigated for their cardioprotective potential in rodent and in vitro models of anthracycline toxicity, with conflicting results. This study evaluated prophylactic omega-3 PUFA supplementation in a large-animal model of anthracycline-induced NICM. METHODS AND RESULTS: Merino sheep were randomized to oral drenching with omega-3 PUFA (fish oil; n 5 8) or olive oil placebo (n 5 9) 3 weeks before commencing repeated intracoronary infusions of doxorubicin (DOX) to induce cardiac dysfunction. Cumulative DOX dose was 3.6 mg/kg. Drenching was continued for 12 weeks after final DOX exposure. Despite significant increases in tissue omega-3 PUFA levels (P < .05 vs placebo), omega-3etreated sheep displayed greater signs of anthracycline cardiotoxicity than placebo animals, consisting of left ventricular dilatation and a greater decline in ejection fraction (P < .05), although myocardial fibrosis burden was similar in both groups. CONCLUSIONS: Dietary intake of omega-3 PUFA fails to prevent and may indeed exacerbate DOX-induced cardiotoxicity. Clinical use of omega-3 supplementation during chemotherapy should be deferred until more information is available regarding the mechanisms of interaction between fatty acids and the myocardium during anthracycline exposure. |
Keywords: | Animal models cardiomyopathy doxorubicin, fish oil |
Rights: | © 2012 Published by Elsevier Inc. |
DOI: | 10.1016/j.cardfail.2012.03.005 |
Published version: | http://dx.doi.org/10.1016/j.cardfail.2012.03.005 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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