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|Title:||'On Periodical Depressions and their Pathogenesis' by Carl Lange (1886)|
|Citation:||History of Psychiatry, 2011; 22(1):108-130|
|Abstract:||Carl Lange was the founding father of neurology in Denmark, authoring several pioneering works within this field; however, these remained largely unknown internationally as he did not have them translated into a major language. He became a pioneer of psychophysiology with his contribution to the so-called James-Lange theory of emotion. His treatise on 'periodical depressions' ('the Lange theory of depressions', 1886), is not only an early historical landmark but also a masterly 'modern' description concerning the nosology and nosography of recurrent depressions. Moreover, it is a landmark in the early history of lithium therapy, sadly ignored by Lange's contemporaries, but which little more than half a century later, with Cade's rediscovery of lithium's therapeutic effect in mood disorders in 1949, ushered in modern psychopharmacology.|
|Keywords:||Carl Lange; depression; history; John Cade; Kraepelin; lithium therapy; melancholy; nosography; nosology; periodicity; psychopharmacology|
|Rights:||© The Author(s) 2011|
|Appears in Collections:||Psychiatry publications|
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