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https://hdl.handle.net/2440/71536
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DC Field | Value | Language |
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dc.contributor.author | Findlay, D. | - |
dc.contributor.author | Atkins, G. | - |
dc.contributor.editor | Wallach, D. | - |
dc.contributor.editor | Kovalenko, A. | - |
dc.contributor.editor | Feldmann, M. | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Advances in TNF Family Research, 2011 / Wallach, D., Kovalenko, A., Feldmann, M. (ed./s), vol.691, pp.337-348 | - |
dc.identifier.isbn | 9781441966117 | - |
dc.identifier.uri | http://hdl.handle.net/2440/71536 | - |
dc.description.abstract | Bone remodelling is the critical process, by which skeletal mass and integrity are controlled. This process is disrupted in a number of bone pathologies, such as osteoporosis, and the focal bone loss that occurs in rheumatoid arthritis, around artificial joint prostheses or that induced by osteolytic tumours. A common feature of conditions that result in a net loss of bone is the presence of elevated levels of pro-inflammatory mediators and evidence has accumulated to show that a chronic inflammatory environment is both catabolic for bone and may also suppress bone formation. Here, we focus on the possible anti-anabolic roles in bone of TNFα and TNF-like weak inducer of apoptosis (TWEAK). | - |
dc.description.statementofresponsibility | David M. Findlay and Gerald J. Atkins | - |
dc.language.iso | en | - |
dc.publisher | Springer | - |
dc.relation.ispartofseries | Advances in Experimental Medicine and Biology ; 691 | - |
dc.rights | © Springer Science+Business Media, LLC 2011 | - |
dc.source.uri | http://dx.doi.org/10.1007/978-1-4419-6612-4_34 | - |
dc.subject | Osteoblasts | - |
dc.subject | Humans | - |
dc.subject | Tumor Necrosis Factors | - |
dc.subject | Bone Morphogenetic Proteins | - |
dc.subject | Receptors, Tumor Necrosis Factor | - |
dc.subject | Bone Remodeling | - |
dc.subject | Signal Transduction | - |
dc.subject | Transcription, Genetic | - |
dc.subject | Calcification, Physiologic | - |
dc.subject | Protein Binding | - |
dc.subject | Osteogenesis | - |
dc.subject | Models, Biological | - |
dc.subject | Wnt Proteins | - |
dc.subject | TWEAK Receptor | - |
dc.title | TWEAK and TNF regulation of sclerostin: a novel pathway for the regulation of bone remodelling | - |
dc.type | Book chapter | - |
dc.identifier.doi | 10.1007/978-1-4419-6612-4_34 | - |
dc.publisher.place | 233 Spring St New York NY 10013 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Atkins, G. [0000-0002-3123-9861] | - |
Appears in Collections: | Aurora harvest Orthopaedics and Trauma publications |
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