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https://hdl.handle.net/2440/71536
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Type: | Book chapter |
Title: | TWEAK and TNF regulation of sclerostin: a novel pathway for the regulation of bone remodelling |
Author: | Findlay, D. Atkins, G. |
Citation: | Advances in TNF Family Research, 2011 / Wallach, D., Kovalenko, A., Feldmann, M. (ed./s), vol.691, pp.337-348 |
Publisher: | Springer |
Publisher Place: | 233 Spring St New York NY 10013 |
Issue Date: | 2011 |
Series/Report no.: | Advances in Experimental Medicine and Biology ; 691 |
ISBN: | 9781441966117 |
Editor: | Wallach, D. Kovalenko, A. Feldmann, M. |
Statement of Responsibility: | David M. Findlay and Gerald J. Atkins |
Abstract: | Bone remodelling is the critical process, by which skeletal mass and integrity are controlled. This process is disrupted in a number of bone pathologies, such as osteoporosis, and the focal bone loss that occurs in rheumatoid arthritis, around artificial joint prostheses or that induced by osteolytic tumours. A common feature of conditions that result in a net loss of bone is the presence of elevated levels of pro-inflammatory mediators and evidence has accumulated to show that a chronic inflammatory environment is both catabolic for bone and may also suppress bone formation. Here, we focus on the possible anti-anabolic roles in bone of TNFα and TNF-like weak inducer of apoptosis (TWEAK). |
Keywords: | Osteoblasts Humans Tumor Necrosis Factors Bone Morphogenetic Proteins Receptors, Tumor Necrosis Factor Bone Remodeling Signal Transduction Transcription, Genetic Calcification, Physiologic Protein Binding Osteogenesis Models, Biological Wnt Proteins TWEAK Receptor |
Rights: | © Springer Science+Business Media, LLC 2011 |
DOI: | 10.1007/978-1-4419-6612-4_34 |
Published version: | http://dx.doi.org/10.1007/978-1-4419-6612-4_34 |
Appears in Collections: | Aurora harvest Orthopaedics and Trauma publications |
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