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Type: Book chapter
Title: TWEAK and TNF regulation of sclerostin: a novel pathway for the regulation of bone remodelling
Author: Findlay, D.
Atkins, G.
Citation: Advances in TNF Family Research, 2011 / Wallach, D., Kovalenko, A., Feldmann, M. (ed./s), pp.337-348
Publisher: Springer
Publisher Place: 233 Spring St New York NY 10013
Issue Date: 2011
Series/Report no.: Advances in Experimental Medicine and Biology ; 691
ISBN: 9781441966117
Statement of
David M. Findlay and Gerald J. Atkins
Abstract: Bone remodelling is the critical process, by which skeletal mass and integrity are controlled. This process is disrupted in a number of bone pathologies, such as osteoporosis, and the focal bone loss that occurs in rheumatoid arthritis, around artificial joint prostheses or that induced by osteolytic tumours. A common feature of conditions that result in a net loss of bone is the presence of elevated levels of pro-inflammatory mediators and evidence has accumulated to show that a chronic inflammatory environment is both catabolic for bone and may also suppress bone formation. Here, we focus on the possible anti-anabolic roles in bone of TNFα and TNF-like weak inducer of apoptosis (TWEAK).
Keywords: Osteoblasts; Humans; Tumor Necrosis Factors; Bone Morphogenetic Proteins; Receptors, Tumor Necrosis Factor; Bone Remodeling; Signal Transduction; Transcription, Genetic; Calcification, Physiologic; Protein Binding; Osteogenesis; Models, Biological; Wnt Proteins
Rights: © Springer Science+Business Media, LLC 2011
RMID: 0020110992
DOI: 10.1007/978-1-4419-6612-4_34
Appears in Collections:Orthopaedics and Trauma publications

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