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https://hdl.handle.net/2440/71522
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dc.contributor.author | Ma, J. | - |
dc.contributor.author | Pilichiewicz, A. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Jones, K. | - |
dc.contributor.author | Horowitz, M. | - |
dc.contributor.author | Rayner, C. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Diabetic Medicine, 2012; 29(5):604-608 | - |
dc.identifier.issn | 0742-3071 | - |
dc.identifier.issn | 1464-5491 | - |
dc.identifier.uri | http://hdl.handle.net/2440/71522 | - |
dc.description.abstract | Aims: Postprandial glucagon-like peptide-1 (GLP-1) secretion and the 'incretin effect' have been reported to be deficient in Type 2 diabetes, but most studies have not controlled for variations in the rate of gastric emptying. We evaluated blood glucose, and plasma insulin, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) responses to intraduodenal glucose in Type 2 diabetes, and compared these with data from healthy controls. Methods: Eight males with well-controlled Type 2 diabetes, managed by diet alone, were studied on four occasions in single-blind, randomized order. Blood glucose, and plasma insulin, GLP-1, and GIP were measured during 120-min intraduodenal glucose infusions at 1 kcal/min (G1), 2 kcal/min (G2) and 4 kcal/min (G4) or saline control. Results: Type 2 patients had higher basal (P < 0.0005) and incremental (P < 0.0005) blood glucose responses to G2 and G4, when compared with healthy controls. In both groups, the stimulation of insulin and GLP-1 by increasing glucose loads was not linear; responses to G1 and G2 were minimal, whereas responses to G4 were much greater (P < 0.005 for each) (incremental area under the GLP-1 curve 224 ± 65, 756 ± 331 and 2807 ± 473 pmol/l.min, respectively, in Type 2 patients and 373 ± 231, 505 ± 161 and 1742 ± 456 pmol/l.min, respectively, in healthy controls). The GLP-1 responses appeared comparable in the two groups. In both groups there was a load-dependent increase in plasma GIP with no difference between them. Conclusions: In patients with well-controlled Type 2 diabetes, blood glucose, insulin and GLP-1 responses are critically dependent on the small intestinal glucose load, and GLP-1 responses are not deficient. | - |
dc.description.statementofresponsibility | J. Ma, A. N. Pilichiewicz, C. Feinle-Bisset, J. M. Wishart, K. L. Jones, M. Horowitz and C. K. Rayner | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.rights | © 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1464-5491.2011.03496.x | - |
dc.subject | glucagon-like peptide 1 | - |
dc.subject | glucose-dependent insulinotropic polypeptide | - |
dc.subject | glycaemic control | - |
dc.title | Effects of variations in duodenal glucose load on glycaemic, insulin, and incretin responses in type 2 diabetes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1464-5491.2011.03496.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
dc.identifier.orcid | Jones, K. [0000-0002-1155-5816] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
dc.identifier.orcid | Rayner, C. [0000-0002-5527-256X] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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