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https://hdl.handle.net/2440/6786
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Type: | Journal article |
Title: | Genetically modified animal models as tools for studying bone and mineral metabolism |
Author: | Davey, R. MacLean, H. McManus, J. Findlay, D. Zajac, J. |
Citation: | Journal of Bone and Mineral Research, 2004; 19(6):882-892 |
Publisher: | Amer Soc Bone & Mineral Res |
Issue Date: | 2004 |
ISSN: | 0884-0431 1523-4681 |
Abstract: | Genetic modification of mice is a powerful tool for the study of bone development and metabolism. This review discusses the advantages and disadvantages of various approaches used in bone-related research and the contributions these studies have made to bone biology. Genetic modification of mice is a powerful tool for the study of bone development and metabolism. This review discusses the advantages and disadvantages of various approaches used in bone-related research and the contributions these studies have made to bone biology. The approaches to genetic modification included in this review are (1) overexpression of genes, (2) global gene knockouts, (3) tissue-specific gene deletion, and (4) gene knock-in models. This review also highlights issues that should be considered when using genetically modified animal models, including the rigorous control of genetic background, use of appropriate control lines, and confirmation of tissue specificity of gene expression where appropriate. This technology provides a unique and powerful way to probe the function of genes and is already revolutionizing our approach to understanding the physiology of bone development and metabolism. |
Keywords: | Bone and Bones Animals Animals, Genetically Modified Mice, Knockout Mice Minerals Models, Animal Phenotype |
DOI: | 10.1359/JBMR.040206 |
Published version: | http://dx.doi.org/10.1359/jbmr.040206 |
Appears in Collections: | Aurora harvest 5 Orthopaedics and Trauma publications |
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